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Cure CML Consortium

H. Jean Khoury Cure CML Consortium

About Us

The H. Jean Khoury Cure CML Consortium was established in 2016 and is a collaborative effort of physicians and researchers at 21 academic medical centers committed to CML research and improving patient care and quality of life.

Ehab Atallah, MD and patient

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Khoury“Galvanized by the spectacular collaboration created by the LAST study, the creation of a CML consortium was simply the next logical thing to do.”

- The late H. Jean Khoury, MD, FACP Winship Cancer Institute of Emory University

Mission

The HJKC3 aims to improve outcomes for patients with chronic myeloid leukemia and to achieve a deeper understanding of CML biology through innovative clinical trials paired with rationally designed correlative studies within a well-coordinated network of CML centers of excellence.

Members

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View the bios of our member/partners

Roswell Park Cancer Institute
James Thompson, MD

Duke University Cancer Institute
Lindsay Rein, MD

Memorial Sloan Kettering Cancer Center
Michael Mauro, MD

Medical College of Wisconsin
Ehab Atallah, MD
Mary Horowitz, MD
Kathryn Flynn, PhD
Michael Deininger, MD, PhD 

Oregon Health & Science University
Brian Druker, MD
Michael Heinrich, MD

H. Lee Moffitt Cancer Center
Kendra Sweet, MD
Javier Pinilla-Ibarz, MD, PhD
Onyee Chan, MD
Zoey Xie, MD, MS

University Health Network- Princess Margaret
Jeffrey Lipton, MD, PhD

Augusta University Research Institute
Jorge Cortes, MD
Vamsi Kota, MD

Barbara Ann Karmanos Cancer Hospital
Jay Yang, MD
Charles Schiffer, MD

The Johns Hopkins University
B. Douglas Smith, MD

Weil Medical College of Cornell University & NY Presbyterian Hospital
Ellen Ritche, MD
Richard Silver, MD

Huntsman Cancer Institute - University of Utah
Srinivas Tantravahi, MD

Fred Hutchinson Cancer Research Center 
Jerald Radich, MD
Vivian Oehler, MD

University of California - San Francisco
Neil Shah, MD, PhD
Kelly Schoenbeck, MD

Mayo Clinic - Minnesota & Jacksonville
Talha Badar, MD

Winship Cancer Institute of Emory University
Anthony Hunter, MD

Dana-Farber Cancer Institute, Dana-Farber/Partners Cancer Care, Inc., Beth Israel Deaconess Medical Center, Inc.
Martha Wadleigh, MD

City of Hope
Haris Ali, MD
Paul Koller, MD

Cleveland Clinic Cancer Center
Sudipto Mukherjee, MD
Akriti Jain, MD

University of Chicago Comprehensive Cancer Center
Richard Larson, MD

University of Alabama
Ravi Bhatia, MD
Omer Jamy, MD

Current Studies

Treatment Free Remission After Combination Therapy With Ruxolitinib Plus Tyrosine Kinase Inhibitors

The purpose of HJKC3-0002 is to determine if adding ruxolitinib (a pill provided by the study) to your TKI for 1 year will lead to a treatment-free remission. We will monitor your CML with PCR testing.

Learn more about HJKC3-0002

Treatment Free Remission After Combination Therapy With Asciminib

The purpose of HJKC3-0003 is to determine if adding asciminib (a pill provided by the study) to your TKI for 1 year will lead to a treatment-free remission. We will monitor your CML with PCR testing.

Learn more about HJKC3-0003

Asciminib as Initial Therapy for Patients With Chronic Myeloid Leukemia in Chronic Phase

The purpose of HJKC3-0004 is to determine whether using asciminib in newly diagnosed CML patients is safe and effective. We will monitor your CML with PCR testing.

Learn more about HJKC3-0004

H. Jean Khoury Cure CML Consortium (HJKC3) Registry

The purpose of HJKC3-0005 is to establish a clinical outcomes and tissue bank registry for patients with CML. With seed funding from the Medical College of Wisconsin, the infrastructure for this registry was established and patient data is being entered from multiple sites across the country. Having an established CML registry will lead to better understanding of CML.

Completed Studies

Questions? CureCML@mcw.edu
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HJKC3-0001 Exploring Patient Decision Making Regarding Discontinuation of Tyrosine Kinase Inhibitors for Chronic Myeloid Leukemia

The results of this study, reveal what patients think about stopping TKI treatment for CML. Researchers conducted in-person interviews with 22 patients, half of whom wanted to try stopping their TKI. Participants included men and women across the typical age range for patients with CML.

There were multiple factors relevant to their decision about stopping TKIs:

  • Thoughts about risk of relapse
  • Reducing side effects
  • Maintaining a treatment that’s working
  • Financial considerations
  • Thoughts about one’s age or social roles (e.g., being a caretaker)
  • Wanting to take fewer medications
  • Being reminded of having CML
  • Need for increased monitoring 

Keep in Mind
Patients in this study were recruited from academic cancer centers only. A larger study that includes patients from both academic and community sites would help confirm the findings.

Learn More about HJKC3-0001

Assessment of Outcomes After Stopping Tyrosine Kinase Inhibitors Among Patients With Chronic Myeloid Leukemia

Using the results of the Life After Stopping TKIs (LAST) study, researchers investigated the possibility of discontinuing TKI therapy among 172 patients who demonstrated a strong and sustained response to treatment. The study explains why this approach was successful for some but not others and details the impacts on patient quality of life.

CML is caused when pieces of two different chromosomes break off and switch places, creating an abnormal gene called BCR-ABL1. This gene then tells the body to create a protein called BCR-ABL. Doctors test levels of BCR-ABL throughout CML treatment to determine how their patients are responding to drug therapy.

This study found that the presence of the BCR-ABL protein at the time of treatment discontinuation may be predictive of molecular recurrence (MRec). Over a three-year period:

  • Patients with NO detectable levels of BCR-ABL at the time of treatment discontinuation had a 10% chance of MRec
  • Patients with detectable levels of BCR-ABL at the time of treatment discontinuation had a 50%-64% chance of MRec

These findings suggest that patients who do not have detectable levels of BCR-ABL at the time of treatment discontinuation may be able to safely scale back the number of monitoring appointments that they attend during treatment-free remission. Doing so may help reduce the stress and anxiety often felt by patients leading up to these check-ups.

During treatment-free remission, there were significant improvements in patient-reported symptoms:

  • 88% of patients had improvement in diarrhea
  • 80% of patients had improvement in fatigue
  • 35% of patients had improvement in depression
  • 21% of patients had improvement in sleep disturbance
  • 5% of patients had improvement in pain interference

The results of this study determined that TKI discontinuation was safe, and 61% of patients remained in treatment-free remission after 3 years.

Learn More about assessment of outcomes

Patient-Reported Functional Outcomes in Patients With Chronic Myeloid Leukemia After Stopping Tyrosine Kinase Inhibitors

This report explains the results of the Life After Stopping TKIs (LAST) study regarding patient changes in function after stopping and restarting TKI treatment.

Patient-reported outcome measurements (PROMs) were collected from 172 chronic myeloid leukemia (CML) patients who discontinued drug therapy over a 36-month period. Of those who remained in treatment-free remission (TFR) at 12 months:

  • 92% reported improvement in social function
  • 71% reported improvements in social isolation
  • 10% reported improvements in satisfaction with sex life
  • 4% reported improvements in physical function

These results can aid patients and physicians in deciding to pursue treatment discontinuation. For those who remain in TFR, functional outcomes improved overall. However, functional outcomes began to worsen for those who restarted treatment.

Learn More about functional outcomes

Patient-and physician-reported pain after tyrosine kinase inhibitor discontinuation among patients with chronic myeloid leukemia

This study describes patient-reported pain in people with chronic myeloid leukemia (CML) after discontinuing tyrosine kinase inhibitor (TKI) treatment.

For CML patients who respond well to TKI, discontinuation of the treatment may allow for achievement of treatment-free remission with improvement of treatment-related symptoms. However, discontinuing TKIs has been associated with physician-reported pain increases in some patients.

Within three months of discontinuation of treatment:

  • 20% of patients had a physician report pain on their behalf
  • 13% of patients self-reported a large increase in pain
  • 11% of patients began taking a new pain medication 

Each of these events was classified as an increase in pain level. There was limited overlap in these measures (that is, few patients had more than one indicator of increased pain).

In total, 60/172 (34.9%) of patients had an increase in pain in the first three months following treatment discontinuation. At six months, pain had returned to a baseline level and continued to decrease beyond that.

Three patients restarted TKI therapy to treat their pain. However, the results of this study show that the pain level trajectory was similar in patients who did and did not restart TKI treatment. This information suggests that restarting TKI treatment may not be more effective at reducing pain than remaining off the treatment.

To remain in TFR, patients should consider the following to manage any discontinuation-associated pain they may experience:

  • Increased physical activity
  • Use of an analgesic or and/or anti-inflammatory pain medication
  • Behavioral/cognitive approaches to pain management

Learn more about reported pain

Patients' perspectives on the definition of cure in chronic myeloid leukemia

A survey of patients with chronic myeloid leukemia (CML) provides a patient definition of cure in CML treatment and outlines patients’ priorities for future CML research.

Researchers surveyed 458 people with CML across the United States. The overwhelming majority of patients (90%) considered the definition of cure for CML as “permanently stopping any CML treatment with no evidence of disease.”

Only 3% considered cure to be “taking a pill daily.”

To reach a treatment-free remission, many patients reported a willingness to add a new therapy to their TKI.

Patients universally supported more research in CML, specifically in:

  • Stopping CML treatment
  • Side effects of CML treatment
  • CML not responding to treatment
  • Long term complications from treatment 
Learn more about patient perspectives

Highlights of Recent Updates in CML Impact on Practice


Dr. Ehab Atallah shares insights and discusses advancements in chronic myeloid leukemia (CML) management. He emphasizes recent updates in therapeutic strategies, including optimizing the use of tyrosine kinase inhibitors (TKIs), addressing resistance and intolerance, and integrating emerging treatments like Asciminib. These updates aim to refine patient care and improve outcomes by leveraging the latest clinical findings. Video provided by the 2024 ASCO® Annual Meeting Insights Hub.

ASCO24 Direct Highlights | Jorge Cortes, MD


Dr. Jorge Cortes from the Georgia Cancer Center summarizes key findings from the 2024 ASCO meeting. He highlights a study on Aiminib as a frontline treatment for chronic myeloid leukemia (CML), which showed promising efficacy and a favorable safety profile compared to standard therapies, potentially advancing CML treatment. He also discusses a retrospective analysis of a condensed Venetoclax-Azacitidine regimen for acute myeloid leukemia (AML), which reduced early mortality and transfusion needs for certain patients, offering a safer alternative for those unfit for intensive therapy.

Lessons in Blood Cancer: How Far We Have Come CML


Dr. Jay Yang, MD, discusses significant advancements in the treatment of chronic myeloid leukemia (CML). He highlights the evolution of therapies, particularly the development and impact of tyrosine kinase inhibitors (TKIs), which have transformed CML from a once-fatal disease into a manageable chronic condition. Dr. Yang also addresses ongoing research efforts aimed at improving patient outcomes and the potential for future therapies to further enhance the quality of life for individuals with CML. This video is provided by the American Society of Clinical Oncology (ASCO) as part of their educational series on blood cancers.

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Mailing Address
Medical College of Wisconsin
8701 Watertown Plank Rd.
Milwaukee, WI 53226


(414) 805-8745
curecml@mcw.edu
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