Michael T. Zimmermann, PhD

Director, Bioinformatics Research and Development Lab, Linda T. and John A. Mellowes Center for Genomic Sciences and Precision Medicine

Locations

Mellowes Center

Research Areas of Interest

Chromatin
Chromosomal Proteins, Non-Histone
Gene Expression Profiling
Genetic Predisposition to Disease
Genetic Variation
Genomics
Human Genetics
Molecular Dynamics Simulation
Multiprotein Complexes
Mutation
Mutation, Missense
Neoplasms

Leadership Positions

Assistant Professor of Bioinformatics - Clinical and Translational Science Institute, Medical College of Wisconsin
Director, Computational Structural Genomics Unit, Linda T. and John A. Mellowes Center for Genomic Sciences and Precision Medicine
MCW Program and Course Director, Joint Program in Bioinformatics between Marquette University and Medical College of Wisconsin
MCW Research Computing Center, Faculty Advisory Committee; Chair (elected, 2022-2024), Co-Chair (elected, 2020-2022), and Member (2020-Present)
Strategic Steering Committee, Data Science Institute, Medical College of Wisconsin
Visiting Assistant Professor – Department of Mathematics, Marquette University

MARK2 variants cause autism spectrum disorder via the downregulation of WNT/β-catenin signaling pathway.

(Gong M, Li J, Qin Z, Machado Bressan Wilke MV, Liu Y, Li Q, Liu H, Liang C, Morales-Rosado JA, Cohen ASA, Hughes SS, Sullivan BR, Waddell V, van den Boogaard MH, van Jaarsveld RH, van Binsbergen E, van Gassen KL, Wang T, Hiatt SM, Amaral MD, Kelley WV, Zhao J, Feng W, Ren C, Yu Y, Boczek NJ, Ferber MJ, Lahner C, Elliott S, Ruan Y, Mignot C, Keren B, Xie H, Wang X, Popp B, Zweier C, Piard J, Coubes C, Mau-Them FT, Safraou H, Innes AM, Gauthier J, Michaud JL, Koboldt DC, Sylvie O, Willems M, Tan WH, Cogne B, Rieubland C, Braun D, McLean SD, Platzer K, Zacher P, Oppermann H, Evenepoel L, Blanc P, El Khattabi L, Haque N, Dsouza NR, Zimmermann MT, Urrutia R, Klee EW, Shen Y, Du H, Rappaport L, Liu CM, Chen X.) Am J Hum Genet. 2024 Nov 07;111(11):2392-2410 PMID: 39419027 SCOPUS ID: 2-s2.0-85207372821 10/18/2024
Changes in Daily Apparent Diffusion Coefficient on Fully Quantitative Magnetic Resonance Imaging Correlate With Established Genomic Pathways of Radiation Sensitivity and Reveal Novel Biologic Associations.

(Hall WA, Mathison AJ, DeVoe E, Tschannen M, Wendt-Andrae J, Straza M, Awan M, Puckett LL, Lawton CAF, Schultz C, Urrutia R, Kerns S, Torres-Roca JF, Li XA, Erickson B, Nevalainen MT, Zimmermann MT, Paulson E.) Int J Radiat Oncol Biol Phys. 2024 Oct 01;120(2):570-578 PMID: 38819340 SCOPUS ID: 2-s2.0-85194948255 05/31/2024
Mutant KRAS inhibitors enter the scene of precision therapeutics for pancreatic cancer.

(Pollin G, Lomberk GA, Mathison AJ, Zimmermann MT, Urrutia R.) J Gastrointest Oncol. 2024 Aug 31;15(4):1996-2001 PMID: 39279937 PMCID: PMC11399826 09/16/2024
Transcriptional Profiling Underscores the Role of Preprocurement Allograft Metabolism and Innate Immune Status on Outcomes in Human Liver Transplantation.

(Kim J, Zimmermann MT, Mathison AJ, Lomberk G, Urrutia R, Hong JC.) Ann Surg Open. 2024 Jun;5(2):e444 PMID: 38911661 PMCID: PMC11191965 06/24/2024
Type I interferon signaling promotes radioresistance in head and neck cancer.

(Zenga J, Awan MJ, Frei A, Massey B, Bruening J, Shukla M, Sharma GP, Shreenivas A, Wong SJ, Zimmermann MT, Mathison AJ, Himburg HA.) Transl Cancer Res. 2024 May 31;13(5):2535-2543 PMID: 38881922 PMCID: PMC11170510 06/17/2024
Cancer-associated polybromo-1 bromodomain 4 missense variants variably impact bromodomain ligand binding and cell growth suppression.

(Bursch KL, Goetz CJ, Jiao G, Nuñez R, Olp MD, Dhiman A, Khurana M, Zimmermann MT, Urrutia RA, Dykhuizen EC, Smith BC.) J Biol Chem. 2024 Apr;300(4):107146 PMID: 38460939 PMCID: PMC11002309 SCOPUS ID: 2-s2.0-85189184192 03/10/2024
Structural and Dynamic Analyses of Pathogenic Variants in PIK3R1 Reveal a Shared Mechanism Associated among Cancer, Undergrowth, and Overgrowth Syndromes.

(Dsouza NR, Cottrell CE, Davies OMT, Tollefson MM, Frieden IJ, Basel D, Urrutia R, Drolet BA, Zimmermann MT.) Life (Basel). 2024 Feb 23;14(3) PMID: 38541623 PMCID: PMC10971029 SCOPUS ID: 2-s2.0-85193266612 03/28/2024
Mutant KRAS inhibitors enter the scene of precision therapeutics for pancreatic cancer

(Pollin G, Lomberk GA, Mathison AJ, Zimmermann MT, Urrutia R.) Journal of Gastrointestinal Oncology. 31 August 2024;15(4):1996-2001 SCOPUS ID: 2-s2.0-85203321495 08/31/2024
Ehmt2 inactivation in pancreatic epithelial cells shapes the transcriptional landscape and inflammation response of the whole pancreas.

(Pollin G, Mathison AJ, de Assuncao TM, Thomas A, Zeighami A, Salmonson A, Liu H, Urrutia G, Vankayala P, Pandol SJ, Hong JC, Zimmermann MT, Iovanna J, Jin VX, Urrutia R, Lomberk G.) Front Genet. 2024;15:1412767 PMID: 38948355 PMCID: PMC11211573 SCOPUS ID: 2-s2.0-85197408751 07/01/2024
Type I interferon signaling promotes radioresistance in head and neck cancer

(Zenga J, Awan MJ, Frei A, Massey B, Bruening J, Shukla M, Sharma GP, Shreenivas A, Wong SJ, Zimmermann MT, Mathison AJ, Himburg HA.) Translational Cancer Research. 2024;13(5):2535-2543 SCOPUS ID: 2-s2.0-85195040296 01/01/2024
Deep computational phenotyping of genomic variants impacting the SET domain of KMT2C reveal molecular mechanisms for their dysfunction.

(Jorge SD, Chi YI, Mazaba JL, Haque N, Wagenknecht J, Smith BC, Volkman BF, Mathison AJ, Lomberk G, Zimmermann MT, Urrutia R.) Front Genet. 2023;14:1291307 PMID: 38090150 PMCID: PMC10715303 SCOPUS ID: 2-s2.0-85179362461 12/13/2023
A multi-layered computational structural genomics approach enhances domain-specific interpretation of Kleefstra syndrome variants in EHMT1.

(Chi YI, Jorge SD, Jensen DR, Smith BC, Volkman BF, Mathison AJ, Lomberk G, Zimmermann MT, Urrutia R.) Comput Struct Biotechnol J. 2023;21:5249-5258 PMID: 37954151 PMCID: PMC10632586 11/13/2023

Michael T. Zimmermann, PhD

Director, Bioinformatics Research and Development Lab, Linda T. and John A. Mellowes Center for Genomic Sciences and Precision Medicine

Locations

Research Areas of Interest

Leadership Positions

Publications