Michael T. Zimmermann, PhD

Director, Bioinformatics Research and Development Lab, Linda T. and John A. Mellowes Center for Genomic Sciences and Precision Medicine

Locations

Mellowes Center

Research Areas of Interest

Chromatin
Chromosomal Proteins, Non-Histone
Gene Expression Profiling
Genetic Predisposition to Disease
Genetic Variation
Genomics
Human Genetics
Molecular Dynamics Simulation
Multiprotein Complexes
Mutation
Mutation, Missense
Neoplasms

Leadership Positions

Assistant Professor of Bioinformatics - Clinical and Translational Science Institute, Medical College of Wisconsin
Director, Computational Structural Genomics Unit, Linda T. and John A. Mellowes Center for Genomic Sciences and Precision Medicine
MCW Program and Course Director, Joint Program in Bioinformatics between Marquette University and Medical College of Wisconsin
MCW Research Computing Center, Faculty Advisory Committee; Chair (elected, 2022-2024), Co-Chair (elected, 2020-2022), and Member (2020-Present)
Strategic Steering Committee, Data Science Institute, Medical College of Wisconsin
Visiting Assistant Professor – Department of Mathematics, Marquette University

Type I interferon signaling promotes radioresistance in head and neck cancer.

(Zenga J, Awan MJ, Frei A, Massey B, Bruening J, Shukla M, Sharma GP, Shreenivas A, Wong SJ, Zimmermann MT, Mathison AJ, Himburg HA.) Transl Cancer Res. 2024 May 31;13(5):2535-2543 PMID: 38881922 PMCID: PMC11170510 06/17/2024
Changes in Daily Apparent Diffusion Coefficient on Fully Quantitative Magnetic Resonance Imaging Correlate With Established Genomic Pathways of Radiation Sensitivity and Reveal Novel Biologic Associations.

(Hall WA, Mathison AJ, DeVoe E, Tschannen M, Wendt-Andrae J, Straza M, Awan M, Puckett LL, Lawton CAF, Schultz C, Urrutia R, Kerns S, Torres-Roca JF, Li XA, Erickson B, Nevalainen MT, Zimmermann MT, Paulson E.) Int J Radiat Oncol Biol Phys. 2024 May 29 PMID: 38819340 SCOPUS ID: 2-s2.0-85194948255 05/31/2024
Cancer-associated polybromo-1 bromodomain 4 missense variants variably impact bromodomain ligand binding and cell growth suppression.

(Bursch KL, Goetz CJ, Jiao G, Nuñez R, Olp MD, Dhiman A, Khurana M, Zimmermann MT, Urrutia RA, Dykhuizen EC, Smith BC.) J Biol Chem. 2024 Apr;300(4):107146 PMID: 38460939 PMCID: PMC11002309 SCOPUS ID: 2-s2.0-85189184192 03/10/2024
Structural and Dynamic Analyses of Pathogenic Variants in PIK3R1 Reveal a Shared Mechanism Associated among Cancer, Undergrowth, and Overgrowth Syndromes.

(Dsouza NR, Cottrell CE, Davies OMT, Tollefson MM, Frieden IJ, Basel D, Urrutia R, Drolet BA, Zimmermann MT.) Life (Basel). 2024 Feb 23;14(3) PMID: 38541623 PMCID: PMC10971029 SCOPUS ID: 2-s2.0-85193266612 03/28/2024
Type I interferon signaling promotes radioresistance in head and neck cancer

(Zenga J, Awan MJ, Frei A, Massey B, Bruening J, Shukla M, Sharma GP, Shreenivas A, Wong SJ, Zimmermann MT, Mathison AJ, Himburg HA.) Translational Cancer Research. 2024;13(5):2535-2543 SCOPUS ID: 2-s2.0-85195040296 01/01/2024
IL6Myc mouse is an immunocompetent model for the development of aggressive multiple myeloma.

(Pisano MD, Sun F, Cheng Y, Parashar D, Zhou V, Jing X, Sompallae R, Abrudan J, Zimmermann MT, Mathison A, Janz S, Pufall MA.) Haematologica. 2023 Dec 01;108(12):3372-3383 PMID: 37439384 PMCID: PMC10690922 SCOPUS ID: 2-s2.0-85178652041 07/13/2023
Writers and readers of H3K9me2 form distinct protein networks during the cell cycle that include candidates for H3K9 mimicry.

(Pollin G, De Assuncao TM, Doria Jorge S, Chi YI, Charlesworth MC, Madden B, Iovanna J, Zimmermann MT, Urrutia R, Lomberk G.) Biosci Rep. 2023 Oct 31;43(10) PMID: 37782747 PMCID: PMC10611923 SCOPUS ID: 2-s2.0-85175273435 10/02/2023
RAG genomic variation causes autoimmune diseases through specific structure-based mechanisms of enzyme dysregulation.

(Haque N, Kawai T, Ratnasinghe BD, Wagenknecht JB, Urrutia R, Notarangelo LD, Zimmermann MT.) iScience. 2023 Oct 20;26(10):108040 PMID: 37854700 PMCID: PMC10579426 10/19/2023
Advanced computational analysis of CD40LG variants in atypical X-linked hyper-IgM syndrome.

(Pazhanisamy A, Jorge SD, Zimmermann MT, Kitcharoensakkul M, Abdalgani M, Khojah A, Victor C, Rueda C, Urrutia R, Abraham RS.) Clin Immunol. 2023 Aug;253:109692 PMID: 37433422 SCOPUS ID: 2-s2.0-85164736502 07/12/2023
Deep computational phenotyping of genomic variants impacting the SET domain of KMT2C reveal molecular mechanisms for their dysfunction.

(Jorge SD, Chi YI, Mazaba JL, Haque N, Wagenknecht J, Smith BC, Volkman BF, Mathison AJ, Lomberk G, Zimmermann MT, Urrutia R.) Front Genet. 2023;14:1291307 PMID: 38090150 PMCID: PMC10715303 SCOPUS ID: 2-s2.0-85179362461 12/13/2023
A multi-layered computational structural genomics approach enhances domain-specific interpretation of Kleefstra syndrome variants in EHMT1.

(Chi YI, Jorge SD, Jensen DR, Smith BC, Volkman BF, Mathison AJ, Lomberk G, Zimmermann MT, Urrutia R.) Comput Struct Biotechnol J. 2023;21:5249-5258 PMID: 37954151 PMCID: PMC10632586 11/13/2023
Beyond structural bioinformatics for genomics with dynamics characterization of an expanded KRAS mutational landscape.

(Ratnasinghe BD, Haque N, Wagenknecht JB, Jensen DR, Valdivia Esparza GK, Leverence EN, Milech De Assuncao T, Mathison AJ, Lomberk G, Smith BC, Volkman BF, Urrutia R, Zimmermann MT.) Comput Struct Biotechnol J. 2023;21:4790-4803 PMID: 37841325 PMCID: PMC10570560 10/16/2023

Linda T. and John A. Mellowes Center for Genomic Sciences and Precision Medicine

Michael T. Zimmermann, PhD

Director, Bioinformatics Research and Development Lab, Linda T. and John A. Mellowes Center for Genomic Sciences and Precision Medicine

Locations

Research Areas of Interest

Leadership Positions

Publications