Fumou Sun, PhD
Assistant Professor
Locations
- TBRC 4885
Hematology and Oncology – Medicine
Discovery & Developmental Therapeutics, Cancer Center
Contact Information
Education
Biography
Dr. Sun is an Assistant Professor of medicine at the Medical College of Wisconsin, Division of Hematology and Oncology. Dr. Sun’s research interests focus on tumor immunotherapy, particularly the novel Chimeric Antigen Receptor T Cell (CAR-T) and multifunctional antibody therapies.
Dr. Sun earned his PhD from China Pharmaceutical University in 2019 and spent several years conducting advanced research in tumor genetics and immunotherapy at the University of Iowa, the Medical College of Wisconsin (MCW), and the University of Arkansas for Medical Sciences. In 2024, Dr. Sun returned to MCW, where he collaborates closely with clinical colleagues to advance the clinical applications of tumor immunotherapy.
Dr. Sun leads multiple funded projects and holds several patent applications. His research has been published in over 30 high-impact journals, including The Journal of Clinical Investigation (JCI), Nature Communications, and Cancer Research. He has received numerous prestigious awards, such as the 24th Annual ECOG-ACRIN Young Investigator Award, the American Society of Hematology (ASH) Abstract Achievement Awards in 2022 and 2023, the Young Investigator Award at the 17th International Myeloma Workshop (IMW) of the International Myeloma Society, and the Scholar-in-Training Award at the AACR Annual Meeting.
Research Interests
- Immunotherapy
- Chimeric Antigen Receptor T Cell Therapy
- Chimeric Antigen Receptor NK Cell Therapy
- Multifunctional Antibody Therapy
- Oncolytic Virus Therapy
- Hematologic Malignancies
- Solid Tumors
Dr. Sun is dedicated to research in the field of tumor immunotherapy, particularly focusing on the development and application of novel Chimeric Antigen Receptor T Cell (CAR-T) immunotherapies. His research focuses on enhancing the therapeutic efficacy of CAR-T cells in treating relapsed and refractory tumors, as well as uncovering the molecular mechanisms underlying therapy resistance.
In addition, Dr. Sun is actively developing combinatory strategies involving CAR-T cells and oncolytic viruses to overcome the challenges associated with solid tumor treatment. He is also committed to innovating multifunctional antibody therapies, aiming to broaden the versatility of antibody-based treatments such as antibody-drug conjugates (ADCs) and bispecific antibodies.
Publications
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Multi-omics reveal immune microenvironment alterations in multiple myeloma and its precursor stages.
(Cheng Y, Sun F, Alapat DV, Wanchai V, Mery D, Siegel ER, Xu H, Johnson S, Guo W, Bailey C, Ashby C, Bauer MA, Hadidi SA, Schinke C, Thanendrarajan S, Zangari M, van Rhee F, Tricot G, Shaughnessy JD Jr, Zhan F.) Blood Cancer J. 2024 Nov 06;14(1):194 PMID: 39505839 PMCID: PMC11541562 11/07/2024
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(Li JR, Arsang-Jang S, Cheng Y, Sun F, D'Souza A, Dhakal B, Hari P, Huang Q, Auer P, Li Y, Urrutia R, Zhan F, Shaughnessy JD Jr, Janz S, Dong J, Cheng C.) Blood Cancer J. 2024 Mar 06;14(1):38 PMID: 38443358 PMCID: PMC10915134 SCOPUS ID: 2-s2.0-85186929795 03/06/2024
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Bispecific BCMA/CD24 CAR-T cells control multiple myeloma growth.
(Sun F, Cheng Y, Wanchai V, Guo W, Mery D, Xu H, Gai D, Siegel E, Bailey C, Ashby C, Al Hadidi S, Schinke C, Thanendrarajan S, Ma Y, Yi Q, Orlowski RZ, Zangari M, van Rhee F, Janz S, Bishop G, Tricot G, Shaughnessy JD Jr, Zhan F.) Nat Commun. 2024 Jan 19;15(1):615 PMID: 38242888 PMCID: PMC10798961 SCOPUS ID: 2-s2.0-85182665152 01/20/2024
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(Sun F, Cheng Y, Chen JR, Wanchai V, Mery DE, Xu H, Gai D, Al Hadidi S, Schinke C, Thanendrarajan S, Zangari M, van Rhee F, Tricot G, Shaughnessy JD Jr, Zhan F.) J Clin Invest. 2024 Jan 02;134(1) PMID: 37883186 PMCID: PMC10760955 10/26/2023
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IL6Myc mouse is an immunocompetent model for the development of aggressive multiple myeloma.
(Pisano MD, Sun F, Cheng Y, Parashar D, Zhou V, Jing X, Sompallae R, Abrudan J, Zimmermann MT, Mathison A, Janz S, Pufall MA.) Haematologica. 2023 Dec 01;108(12):3372-3383 PMID: 37439384 PMCID: PMC10690922 SCOPUS ID: 2-s2.0-85178652041 07/13/2023
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High NEK2 expression in myeloid progenitors suppresses T cell immunity in multiple myeloma.
(Cheng Y, Sun F, Alapat DV, Wanchai V, Mery D, Guo W, Cao H, Zhu Y, Ashby C, Bauer MA, Nookaew I, Siegel ER, Ying J, Chen JR, Gai D, Peng B, Xu H, Bailey C, Al Hadidi S, Schinke C, Thanendrarajan S, Zangari M, Chesi M, Bergsagel PL, van Rhee F, Janz S, Tricot G, Shaughnessy JD Jr, Zhan F.) Cell Rep Med. 2023 Oct 17;4(10):101214 PMID: 37794587 PMCID: PMC10591052 SCOPUS ID: 2-s2.0-85173718596 10/05/2023
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A gene signature can predict risk of MGUS progressing to multiple myeloma.
(Sun F, Cheng Y, Ying J, Mery D, Al Hadidi S, Wanchai V, Siegel ER, Xu H, Gai D, Ashby TC, Bailey C, Chen JR, Schinke C, Thanendrarajan S, Zangari M, Janz S, Barlogie B, Van Rhee F, Tricot G, Shaughnessy JD Jr, Zhan F.) J Hematol Oncol. 2023 Jun 29;16(1):70 PMID: 37386588 PMCID: PMC10308756 SCOPUS ID: 2-s2.0-85163879552 06/30/2023
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αVEGFR2-MICA fusion antibodies enhance immunotherapy effect and synergize with PD-1 blockade.
(Pan M, Wang F, Nan L, Yang S, Qi J, Xie J, Shao S, Zou H, Wang M, Sun F, Zhang J.) Cancer Immunol Immunother. 2023 Apr;72(4):969-984 PMID: 36227341 PMCID: PMC10991987 10/14/2022
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CST6 suppresses osteolytic bone disease in multiple myeloma by blocking osteoclast differentiation.
(Gai D, Chen JR, Stewart JP, Nookaew I, Habelhah H, Ashby C, Sun F, Cheng Y, Li C, Xu H, Peng B, Garg TK, Schinke C, Thanendrarajan S, Zangari M, Chen F, Barlogie B, van Rhee F, Tricot G, Shaughnessy JD Jr, Zhan F.) J Clin Invest. 2022 Sep 15;132(18) PMID: 35881476 PMCID: PMC9479617 07/27/2022
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FOXM1 regulates glycolysis and energy production in multiple myeloma.
(Cheng Y, Sun F, Thornton K, Jing X, Dong J, Yun G, Pisano M, Zhan F, Kim SH, Katzenellenbogen JA, Katzenellenbogen BS, Hari P, Janz S.) Oncogene. 2022 Aug;41(32):3899-3911 PMID: 35794249 PMCID: PMC9355869 SCOPUS ID: 2-s2.0-85133568311 07/07/2022
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Baicalin regulates autophagy to interfere with small intestinal acute graft-versus-host disease.
(Sun X, Pisano M, Xu L, Sun F, Xu J, Zheng W, Liu X, Zhang Y, Sun R, Cui X.) Sci Rep. 2022 Apr 21;12(1):6551 PMID: 35449393 PMCID: PMC9023573 04/23/2022
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Critical Role for Cap-Independent c-MYC Translation in Progression of Multiple Myeloma.
(Shi Y, Sun F, Cheng Y, Holmes B, Dhakal B, Gera JF, Janz S, Lichtenstein A.) Mol Cancer Ther. 2022 Apr 01;21(4):502-510 PMID: 35086951 PMCID: PMC8983490 SCOPUS ID: 2-s2.0-85128145497 01/29/2022