Diane S. Book, MD

Professor

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Locations

Froedtert Hospital
Neuroscience Center – Specialty Clinics

Specialties

Behavioral Neurology
Neurology

Languages

English

Neurology-Appointment by Referral Only

(414) 955-6688

Education

MD - Doctor of Medicine

Biography

Appointments
Medical Director, Froedtert & the Medical College of Wisconsin Stroke Program

Specialty
Adult Neurology

Subspecialties
Stroke and Cerebrovascular Disease, stroke clinic quality, acute stroke therapy, small vessel diseases
CADASIL
Dementia

Training
Resident, Neurology, Medical College of Wisconsin Affiliated Hospitals, Milwaukee, WI, 1991-1995.
Fellow, Behavioral Neurology Fellowship, Stroke/Dementia, Medical College of Wisconsin, Milwaukee, WI, 1995-1996.

Societies
American Medical Association
American Heart Association Stroke Council
American Academy of Neurology | Wisconsin Stroke Committee

View Faculty Collaboration Database profile

Honors and Awards

Alpha Omega Alpha Medical Honor Society
American Medical Women's Association Scholastic Achievement Award
Phi Beta Kappa
Phi Kappa Phi
Best Doctor 2017-2018
Top Doctors
Froedtert & the Medical College Stroke & Neurovascular Program - receives Joint Commission Primary Stroke Center Certification 2006-present, and American Heart Association Performance Achievement Awards for clinical care quality

Research Interests

Ischemic Stroke Evaluation and Management, Hyperacute Stroke, Stroke Education, Stroke Care Quality, Dementias

Current and Previous Research Projects

Secondary Prevention of Small Subcortical Strokes (SPS3); NIH/NINDS , local Principal Investigator

Semantic network activation facilitates oral word reading in chronic aphasia.

(Pillay SB, Gross WL, Heffernan J, Book DS, Binder JR.) Brain Lang. 2022 Oct;233:105164 PMID: 35933744 PMCID: PMC9948519 SCOPUS ID: 2-s2.0-85135407900 08/08/2022
The Neural Basis of Successful Word Reading in Aphasia.

(Pillay SB, Gross WL, Graves WW, Humphries C, Book DS, Binder JR.) J Cogn Neurosci. 2018 Apr;30(4):514-525 PMID: 29211656 PMCID: PMC9926535 SCOPUS ID: 2-s2.0-85042764522 12/07/2017
Lesion localization of speech comprehension deficits in chronic aphasia.

(Pillay SB, Binder JR, Humphries C, Gross WL, Book DS.) Neurology. 2017 Mar 07;88(10):970-975 PMID: 28179469 PMCID: PMC5333516 SCOPUS ID: 2-s2.0-85014816931 02/10/2017
Surface errors without semantic impairment in acquired dyslexia: a voxel-based lesion-symptom mapping study.

(Binder JR, Pillay SB, Humphries CJ, Gross WL, Graves WW, Book DS.) Brain. 2016 May;139(Pt 5):1517-26 PMID: 26966139 PMCID: PMC5006249 SCOPUS ID: 2-s2.0-84966648862 03/12/2016
Cerebral localization of impaired phonological retrieval during rhyme judgment.

(Pillay SB, Stengel BC, Humphries C, Book DS, Binder JR.) Ann Neurol. 2014 Nov;76(5):738-46 PMID: 25164766 PMCID: PMC4214892 SCOPUS ID: 2-s2.0-84912085803 08/29/2014
Closure of patent foramen ovale versus medical therapy after cryptogenic stroke.

(Carroll JD, Saver JL, Thaler DE, Smalling RW, Berry S, MacDonald LA, Marks DS, Tirschwell DL, RESPECT Investigators.) N Engl J Med. 2013 Mar 21;368(12):1092-100 PMID: 23514286 03/22/2013
Effects of clopidogrel added to aspirin in patients with recent lacunar stroke.

(SPS3 Investigators, Benavente OR, Hart RG, McClure LA, Szychowski JM, Coffey CS, Pearce LA.) N Engl J Med. 2012 Aug 30;367(9):817-25 PMID: 22931315 PMCID: PMC4067036 08/31/2012
High-dose atorvastatin after stroke or transient ischemic attack.

(Amarenco P, Bogousslavsky J, Callahan A 3rd, Goldstein LB, Hennerici M, Rudolph AE, Sillesen H, Simunovic L, Szarek M, Welch KM, Zivin JA, Stroke Prevention by Aggressive Reduction in Cholesterol Levels (SPARCL) Investigators.) N Engl J Med. 2006 Aug 10;355(6):549-59 PMID: 16899775 08/11/2006
Clipping the Eagle's wings: treatment of an unusual cause of transient cerebral ischemia.

(Varelas PN, Sinson G, Rand S, Book D.) Neurology. 2005 Jan 25;64(2):393-4 PMID: 15668456 SCOPUS ID: 2-s2.0-12544250987 01/26/2005
Design and baseline characteristics of the stroke prevention by aggressive reduction in cholesterol levels (SPARCL) study.

(Amarenco P, Bogousslavsky J, Callahan AS, Goldstein L, Hennerici M, Sillsen H, Welch MA, Zivin J, SPARCL Investigators.) Cerebrovasc Dis. 2003;16(4):389-95 PMID: 14584489 SCOPUS ID: 2-s2.0-0141676273 10/31/2003
Markers of increased risk of intracerebral hemorrhage after intravenous recombinant tissue plasminogen activator therapy for acute ischemic stroke in clinical practice: the Multicenter rt-PA Stroke Survey.

(Tanne D, Kasner SE, Demchuk AM, Koren-Morag N, Hanson S, Grond M, Levine SR.) Circulation. 2002 Apr 09;105(14):1679-85 PMID: 11940547 SCOPUS ID: 2-s2.0-0037046216 04/10/2002
Initial clinical experience with IV tissue plasminogen activator for acute ischemic stroke: a multicenter survey. The t-PA Stroke Survey Group.

(Tanne D, Bates VE, Verro P, Kasner SE, Binder JR, Patel SC, Mansbach HH, Daley S, Schultz LR, Karanjia PN, Scott P, Dayno JM, Vereczkey-Porter K, Benesch C, Book D, Coplin WM, Dulli D, Levine SR.) Neurology. 1999 Jul 22;53(2):424-7 PMID: 10430444 SCOPUS ID: 2-s2.0-0033595255 08/03/1999