header-logo
Research Lab Bench
Physiology
Gaurav Kumar, PhD

Gaurav Kumar, PhD

Postdoctoral Researcher

Contact Information

Education

PhD, Biochemistry, University of Delhi, South Campus, New Delhi, India, 2021
MBiochem, H.N.B Garhwal University, Sri Nagar, Uttarakhand, India, 2010

Research Interests

Research Interest: Cardiovascular Biology, Physiology, Hypertension

Biography: Many healthcare organizations have declared hypertension as a global health burden that is indeed responsible for significantly high mortality rates. Dr. Sigmund's lab has previously identified phosphodiesterase (PDE5) as an interacting partner of Rho-related BTB domain containing 1 (RhoBTB1) protein. RhoBTB1 regulates PDE5 expression and activity and therefore intracellular cGMP levels. In contrast, restoration of RhoBTB1 expression in RhoBTB1-deficient states results in improvement of cardiovascular status in a mouse model of hypertension.

I am currently dealing with the identification of novel interacting protein partners with RhoBTB1, PDE5a, and Cullins, which are some of the interesting candidates involved in hypertension and associated cardiovascular impairments. Using molecular and cellular approaches, I plan to use specific domains of RhoBTB1 as bait to decipher the possible interaction of novel targets, that in turn, can open new therapeutic avenues to counter hypertension and related cardiovascular events.

© 2024 Medical College of Wisconsin.  All rights reserved.  | Terms and Privacy 

Non-Discrimination Statement
The Medical College of Wisconsin (MCW) is committed to fostering a diverse community of outstanding faculty, staff, and students, as well as ensuring equal educational opportunity, employment, and access to services, programs, and activities, without regard to an individual's race, color, national origin, religion, age, disability, sex, gender identity/expression, sexual orientation, marital status, pregnancy, predisposing genetic characteristic, or military status. Employees, students, applicants or other members of the MCW community (including but not limited to vendors, visitors, and guests) may not be subjected to harassment that is prohibited by law or treated adversely or retaliated against based upon a protected characteristic. MCW’s policy as well as federal and state laws and regulations prohibit unlawful discrimination and harassment.