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Medical College of Wisconsin School of Graduate Studies U1-Research 2F Microscope Lab-Grad-hero
Tyler Trask

Tyler Trask

Graduate Student

Program

  • Biophysics

Contact Information

Biography

Mentor: Fabrizio Marinelli, PhD
Year Entered MCW: 2024
Previous Education: BS Neuroscience, University of Michigan, 2017; MHA, Cornell University, 2019

Research Interests

My research focuses on investigating the molecular mechanisms underlying membrane transport and signaling, using a combination of computational and experimental approaches, with an emphasis on quantitative methods and rational design. This research has broad implications for developing new therapies, particularly in addressing drug resistance, cancer, and neurological diseases. With a background in neuroscience and pharmaceutical management, coupled with training in opioid pharmacology, I aim to apply these methods to accelerate the discovery and development of innovative treatments for neurological disorders and mental health conditions.

Publications

Nastase AF, Griggs NW, Anand JP, Fernandez TJ, Harland AA, Trask TJ, Jutkiewicz EM, Traynor JR, Mosberg HI. Synthesis and pharmacological evaluation of novel C-8 substituted tetrahydroquinolines as balanced-affinity mu/delta opioid ligands for the treatment of pain. ACS Chem Neurosci. 2018 April 20; 9(7): 1840-1848. DOI: 10.1021/acschemneuro.8b00139

Harland AA, Pogozheva ID, Griggs NW, Trask TJ, Traynor JR, Mosberg HI. Placement of hydroxy moiety on pendant of peptidomimetic scaffold modulates mu and kappa opioid receptor efficacy. ACS Chem Neurosci. 2017 August 10; 8(11): 2549-2557. DOI: 10.1021/acschemneuro.7b00284

Bender AM, Griggs NW, Gao C, Trask TJ, Traynor JR, Mosberg HI. Rapid synthesis of boc-2′,6′-dimethyl L tyrosine and derivatives and incorporation into opioid peptidomimetics. ACS Med Chem Lett. 2015 Oct 19; 6(12): 1199-1203. DOI: 10.1021/acsmedchemlett.5b00344


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