Tyler Waltz, PhD

Neuroscience, pain, electrophysiology, peripheral neuropathy

Research Experience

Medical College of Wisconsin, 2019-2023
Advisor: Cheryl Stucky, PhD
Project: Mechanisms of pain in Fabry disease (F31NS122380)

National Institute on Aging, Baltimore MD, 2016-2017
Advisor: Dr. Vilhelm A. Bohr
Project: Pharmacological methods to extend healthspan and lifespan.

Arcadia University, College of Arts and Sciences, Glenside, PA, 2014-2015
Advisor: Dr. Chad Hoefler
Project: Sex-differences in aposematic prey behavior under predation cues.

Publications

Waltz TB, Chao D, Prodoehl EK, Enders JD, Ehlers VL, Dharanikota BS, Dahms NM, Isaeva E, Hogan QH, Pan B, Stucky CL. Fabry disease Schwann cells release p11 to induce sensory neuron hyperactivity. JCI Insight. 2024 Mar 7;9(8):e172869. doi: 10.1172/jci.insight.172869. PMID: 38646936; PMCID: PMC11141882.

Rodríguez García DM, Szabo A, Mikesell AR, Zorn SJ, Tsafack UK, Sriram A, Waltz TB, Enders JD, Mecca CM, Stucky CL, Sadler KE. High-speed imaging of evoked rodent mechanical behaviors yields variable results that are not predictive of inflammatory injury. Pain. 2024 Jul 1;165(7):1569-1582. doi: 10.1097/j.pain.0000000000003174. Epub 2024 Feb 2. PMID: 38314814; PMCID: PMC11189758.

Waltz TB, Chao D, Prodoehl EK, Ehlers VL, Dharanikota BS, Dahms NM, Isaeva E, Hogan QH, Pan B, Stucky CL. Schwann cell release of p11 induces sensory neuron hyperactivity in Fabry disease. bioRxiv [Preprint]. 2023 May 28:2023.05.26.542493. doi: 10.1101/2023.05.26.542493. Update in: JCI Insight. 2024 Mar 7;9(8):e172869. doi: 10.1172/jci.insight.172869. PMID: 37292928; PMCID: PMC10245981.

Sadler KE, Atkinson SN, Ehlers VL, Waltz TB, Hayward M, Rodríguez García DM, Salzman NH, Stucky CL, Brandow AM. Gut microbiota and metabolites drive chronic sickle cell disease pain. bioRxiv [Preprint]. 2023 Apr 28:2023.04.25.538342. doi: 10.1101/2023.04.25.538342. PMID: 37163080; PMCID: PMC10168372.

Burand AJ Jr, Waltz TB, Manis AD, Hodges MR, Stucky CL. HomeCageScan analysis reveals ongoing pain in Fabry rats. Neurobiol Pain. 2023 Jan 5;13:100113. doi: 10.1016/j.ynpai.2022.100113. PMID: 36660199; PMCID: PMC9843259.

Waltz TB, Burand AJ Jr, Sadler KE, Stucky CL. Sensory-specific peripheral nerve pathology in a rat model of Fabry disease. Neurobiol Pain. 2021 Sep 2;10:100074. doi: 10.1016/j.ynpai.2021.100074. PMID: 34541380; PMCID: PMC8437817.

Sadler KE, Lewis TR, Waltz TB, Besharse JC, Stucky CL. Peripheral nerve pathology in sickle cell disease mice. Pain Rep. 2019 Jun 27;4(4):e765. doi: 10.1097/PR9.0000000000000765. PMID: 31579856; PMCID: PMC6728004.

Fang EF, Waltz TB… Bohr VA, Becker KG. Tomatidine enhances lifespan and healthspan in C. elegans through mitophagy induction via the SKN-1/Nrf2 pathway. Sci Rep. 2017.

Waltz TB, Fivenson EM… Bohr VA, Fang EF. Sarcopenia, aging and prospective interventional strategies. Curr Med Chem. 2017.

Mitchell SJ, Bernier M… Waltz TB… Baur JA, de Cabo R. Nicotinamide Improves Aspects of Healthspan, but Not Lifespan, in Mice. Cell Metab. 2018.

Fang EF, Kassahun H… Waltz TB… Nilsen H, Bohr VA. NAD(+) Replenishment Improves Lifespan and Healthspan in Ataxia Telangiectasia Models via Mitophagy and DNA Repair. Cell Metab. 2016.

Waltz, TB, Fang EF, Bohr VA. Compound in green tomatoes extends lifespan, healthspan in animal models, human cells. Featured Research article, NIA website. Edited by Chip Rose, Public Affairs Specialist, NIA. Nov. 2017.

Mitchell SJ, Bernier M… Waltz TB… Baur JA, de Cabo R. Nicotinamide Improves Aspects of Healthspan, but Not Lifespan, in Mice. Cell Metab. 2018.

General Interests

Video games, cooking, and skiing