Jonathan S. Marchant, MA, PhD
Marcus Professor & Chair
Locations
- Cell Biology, Neurobiology & Anatomy, BSB4
Contact Information
Education
Postdoctoral, Neurobiology & Behavior, UC Irvine, CA
Biography
Dr. Marchant received his PhD in Pharmacology from the University of Cambridge in the laboratory of Colin Taylor, and then performed post-doctoral training as a Wellcome Trust Training Fellow in Ian Parker’s laboratory in the Department of Neurobiology and Behavior at the University of California-Irvine. He was a Faculty Member in the Department of Pharmacology at the University of Minnesota from 2002-2017, until joining MCW as the Marcus Chair of Cell Biology, Neurobiology and Anatomy in 2017.
In a groundbreaking study, Dr. Marchant and his team identified a new class of compounds called benzamidoquinazolinones (BZQs) that show promise as broad-spectrum treatments for trematode infections in humans.
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Research Areas of Interest
- Antiparasitic Agents
- Calcium Channels
- Calcium Signaling
- Endoplasmic Reticulum
- Endosomes
- Ion Channels
- Lysosomes
- Schistosomiasis
Research Experience
- Fluorescent Dyes
- Gene Silencing
- High-Throughput Screening Assays
- Membrane Proteins
- Microinjections
- Microscopy, Confocal
- Planarians
- RNA Interference
- Signal Transduction
Research Interests
Publications
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Target-based discovery of a broad-spectrum flukicide.
(Sprague DJ, Park SK, Gramberg S, Bauer L, Rohr CM, Chulkov EG, Smith E, Scampavia L, Spicer TP, Haeberlein S, Marchant JS.) Nat Struct Mol Biol. 2024 May 07 PMID: 38714890 SCOPUS ID: 2-s2.0-85192232257 05/08/2024
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Progress interrogating TRPMPZQ as the target of praziquantel.
(Marchant JS.) PLoS Negl Trop Dis. 2024 Feb;18(2):e0011929 PMID: 38358948 PMCID: PMC10868838 SCOPUS ID: 2-s2.0-85185235832 02/15/2024
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The anthelmintic meclonazepam activates a schistosome transient receptor potential channel.
(Park SK, Sprague DJ, Rohr CM, Chulkov EG, Petrow I, Kumar S, Marchant JS.) J Biol Chem. 2024 Jan;300(1):105528 PMID: 38043794 PMCID: PMC10788528 SCOPUS ID: 2-s2.0-85180267343 12/04/2023
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(Gunaratne GS, Kumar S, Lin-Moshier Y, Slama JT, Brailoiu E, Patel S, Walseth TF, Marchant JS.) J Biol Chem. 2023 Dec;299(12):105378 PMID: 37866635 PMCID: PMC10685313 SCOPUS ID: 2-s2.0-85176734898 10/23/2023
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(Sprague DJ, Kaethner M, Park SK, Rohr CM, Harris JL, Maillard D, Spangenberg T, Lundström-Stadelmann B, Marchant JS.) ACS Med Chem Lett. 2023 Nov 09;14(11):1537-1543 PMID: 37970586 PMCID: PMC10641913 SCOPUS ID: 2-s2.0-85177728490 11/16/2023
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Target-based discovery of a broad spectrum flukicide.
(Sprague DJ, Park SK, Gramberg S, Bauer L, Rohr CM, Chulkov EG, Smith E, Scampavia L, Spicer TP, Haeberlein S, Marchant JS.) bioRxiv. 2023 Sep 22 PMID: 37790347 PMCID: PMC10542552 10/04/2023
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(Friedrich L, Park SK, Ballard P, Ho Baeurle TH, Maillard D, Bödding M, Keiser J, Marchant JS, Spangenberg T.) ChemMedChem. 2023 Sep 15;18(18):e202300140 PMID: 37272317 PMCID: PMC10530395 SCOPUS ID: 2-s2.0-85161895130 06/05/2023
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Convergent activation of two-pore channels mediated by the NAADP-binding proteins JPT2 and LSM12.
(Gunaratne GS, Brailoiu E, Kumar S, Yuan Y, Slama JT, Walseth TF, Patel S, Marchant JS.) Sci Signal. 2023 Aug 22;16(799):eadg0485 PMID: 37607218 PMCID: PMC10639087 SCOPUS ID: 2-s2.0-85168792524 08/22/2023
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Convergent activation of Ca2+ permeability in two-pore channel 2 through distinct molecular routes.
(Saito R, Mu Q, Yuan Y, Rubio-Alarcón M, Eznarriaga M, Zhao P, Gunaratne G, Kumar S, Keller M, Bracher F, Grimm C, Brailoiu E, Marchant JS, Rahman T, Patel S.) Sci Signal. 2023 Aug 22;16(799):eadg0661 PMID: 37607219 PMCID: PMC10639088 SCOPUS ID: 2-s2.0-85168781300 08/22/2023
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Use the force, fluke: Ligand-independent gating of Schistosoma mansoni ion channel TRPMPZQ.
(Chulkov EG, Isaeva E, Stucky CL, Marchant JS.) Int J Parasitol. 2023 Jul;53(8):427-434 PMID: 36610555 PMCID: PMC10258140 SCOPUS ID: 2-s2.0-85146298174 01/08/2023
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(Chulkov EG, Palygin O, Yahya NA, Park SK, Marchant JS.) Int J Parasitol. 2023 Jul;53(8):415-425 PMID: 36610556 PMCID: PMC10258134 SCOPUS ID: 2-s2.0-85146083227 01/08/2023
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Molecular and cellular basis of praziquantel action in the cardiovascular system.
(Yahya NA, Lanham JK, Sprague DJ, Palygin O, McCorvy JD, Marchant JS.) Am J Physiol Cell Physiol. 2023 Feb 01;324(2):C573-C587 PMID: 36622066 PMCID: PMC9942900 SCOPUS ID: 2-s2.0-85148113561 01/10/2023