Roy Silverstein, MD

Professor and Chair Emeritus, Department of Medicine; Associate Director, Medical Scientist Training Program; Senior Investigator, Versiti Blood Research Institute; Professor of Cell Biology and Physiology

Locations

Medical College of Wisconsin
Department of Medicine
Division of Hematology and Oncology

Biography

Roy Silverstein, MD, is Professor and Chair Emeritus of Medicine at the Medical College of Wisconsin Division of Hematology and Oncology. He graduated from Emory University School of Medicine in 1979, and then completed his residency and fellowship in hematology and medical oncology at New York Hospital-Cornell Medical Center. Dr. Silverstein is board certified in Internal Medicine, Hematology, and Oncology.

Research Interests

Dr. Silverstein's current research interests include laboratory based translational research on the molecular, cellular, and genetic causes of common human vascular disorders, including thrombosis, angiogenesis, and atherosclerosis. His clinical interests include thrombosis, hemostasis, and myeloproliferative neoplasms. Dr. Silverstein has published over 200 articles which include papers in Blood, Nature Medicine, J. Clinical Invest, and J. Exp Med.

Distinguishing ASH clinical practice guidelines from other forms of ASH clinical advice.

(Cuker A, Kunkle R, Bercovitz RS, Byrne M, Djulbegovic B, Haberichter SL, Holter-Chakrabarty J, Lottenberg R, Pai M, Rezende SM, Seftel MD, Silverstein RL, Terrell DR, Cheung MC.) Blood Adv. 2024 Jun 11;8(11):2960-2963 PMID: 38593461 PMCID: PMC11302374 SCOPUS ID: 2-s2.0-85196395496 04/09/2024
Targeting Cysteine Oxidation in Thrombotic Disorders.

(Yang M, Silverstein RL.) Antioxidants (Basel). 2024 Jan 09;13(1) PMID: 38247507 PMCID: PMC10812781 01/22/2024
CD36 restricts lipid-associated macrophages accumulation in white adipose tissues during atherogenesis.

(Chen V, Zhang J, Chang J, Beg MA, Vick L, Wang D, Gupta A, Wang Y, Zhang Z, Dai W, Kim M, Song S, Pereira D, Zheng Z, Sodhi K, Shapiro JI, Silverstein RL, Malarkannan S, Chen Y.) Front Cardiovasc Med. 2024;11:1436865 PMID: 39156133 PMCID: PMC11327822 SCOPUS ID: 2-s2.0-85201434395 08/19/2024
Intracellular tPA-PAI-1 interaction determines VLDL assembly in hepatocytes.

(Dai W, Zhang H, Lund H, Zhang Z, Castleberry M, Rodriguez M, Kuriakose G, Gupta S, Lewandowska M, Powers HR, Valmiki S, Zhu J, Shapiro AD, Hussain MM, López JA, Sorci-Thomas MG, Silverstein RL, Ginsberg HN, Sahoo D, Tabas I, Zheng Z.) Science. 2023 Sep;381(6661):eadh5207 PMID: 37651538 PMCID: PMC10697821 SCOPUS ID: 2-s2.0-85169348601 08/31/2023
Identifying experts for clinical practice guidelines: perspectives from the ASH Guideline Oversight Subcommittee.

(Byrne M, Mattison R, Bercovitz R, Lottenberg R, Rezende SM, Silverstein R, Terrell D, Kunkle R, Smith D, Bollard C, Haberichter S, Holter-Chakrabarty J, Pai M, Cheung M, Cuker A, Seftel M, Djulbegovic B.) Blood Adv. 2023 Aug 22;7(16):4323-4326 PMID: 37186271 PMCID: PMC10424133 05/15/2023
A CD36 transmembrane domain peptide interrupts CD36 interactions with membrane partners on macrophages and inhibits atherogenic functions.

(Huang W, Li R, Zhang J, Cheng Y, Ramakrishnan DP, Silverstein RL.) Transl Res. 2023 Apr;254:68-76 PMID: 36377115 PMCID: PMC10863465 SCOPUS ID: 2-s2.0-85143169438 11/16/2022
Contribution of adipocyte Na/K-ATPase α1/CD36 signaling induced exosome secretion in response to oxidized LDL.

(Pillai SS, Pereira DG, Zhang J, Huang W, Beg MA, Knaack DA, de Souza Goncalves B, Sahoo D, Silverstein RL, Shapiro JI, Sodhi K, Chen Y.) Front Cardiovasc Med. 2023;10:1046495 PMID: 37180782 PMCID: PMC10174328 SCOPUS ID: 2-s2.0-85159873988 05/14/2023
Na/K-ATPase suppresses LPS-induced pro-inflammatory signaling through Lyn.

(Zhang J, Chang J, Beg MA, Huang W, Zhao Y, Dai W, Wu X, Cui W, Pillai SS, Lakhani HV, Sodhi K, Shapiro JI, Sahoo D, Zheng Z, Silverstein RL, Chen Y.) iScience. 2022 Sep 16;25(9):104963 PMID: 36072548 PMCID: PMC9442361 SCOPUS ID: 2-s2.0-85137074779 09/09/2022
CD36, a signaling receptor and fatty acid transporter that regulates immune cell metabolism and fate.

(Chen Y, Zhang J, Cui W, Silverstein RL.) J Exp Med. 2022 Jun 06;219(6) PMID: 35438721 PMCID: PMC9022290 SCOPUS ID: 2-s2.0-85128794972 04/20/2022
Plasma Membrane Localization of CD36 Requires Vimentin Phosphorylation; A Mechanism by Which Macrophage Vimentin Promotes Atherosclerosis.

(Kim SY, Jeong SJ, Park JH, Cho W, Ahn YH, Choi YH, Oh GT, Silverstein RL, Park YM.) Front Cardiovasc Med. 2022;9:792717 PMID: 35656400 PMCID: PMC9152264 06/04/2022
Development of an arteriolar niche and self-renewal of breast cancer stem cells by lysophosphatidic acid/protein kinase D signaling

(Jiang Y, Guo Y, Hao J, Guenter R, Lathia J, Beck AW, Hattaway R, Hurst D, Wang QJ, Liu Y, Cao Q, Krontiras H, Chen H, Silverstein R, Ren B.) Communications Biology. December 2021;4(1) SCOPUS ID: 2-s2.0-85108778647 12/01/2021
Hypertriglyceridemia during hospitalization independently associates with mortality in patients with COVID-19.

(Dai W, Lund H, Chen Y, Zhang J, Osinski K, Jones SZ, Kreuziger LB, López JA, Benjamin IJ, Silverstein RL, Zheng Z.) J Clin Lipidol. 2021;15(5):724-731 PMID: 34470719 PMCID: PMC8353976 SCOPUS ID: 2-s2.0-85114047849 09/03/2021

Roy Silverstein, MD

Professor and Chair Emeritus, Department of Medicine; Associate Director, Medical Scientist Training Program; Senior Investigator, Versiti Blood Research Institute; Professor of Cell Biology and Physiology

Locations

Biography

Research Interests

Publications