Scheduling, Location, and Hours of Operation
Cryo-EM facility: Health Research Center, Basement
X-ray Crystallography: Translational Biomedical Research building, 2nd floor
Monday–Friday from 8 a.m.-5 p.m.
Services and Technologies
The Protein Purification unit produces homogeneous, high-quality proteins well-suited for downstream biophysical studies and structure determination.
The Structure Determination unit employs X-ray crystallography, Cryo-EM, and advanced AI-assisted analytical tools for structure determination and imaging.
Leadership
Notable Publications
CXXC5 drove inflammation and ovarian cancer proliferation via transcriptional activation of ZNF143 and EGR1. (Geng T, Sun Q, He J, Chen Y, Cheng W, Shen J, Liu B, Zhang M, Wang S, Asan K, Song M, Gao Q, Song Y, Liu R, Liu X, Ding Y, Jing A, Ye X, Ren H, Zeng K, Zhou Y, Zhang B, Ma S, Liu W, Liu S, Ji J) Cell Signal 2024 Jul;119:111180. PMID: 38642782; DOI: 10.1016/j.cellsig.2024.111180; Scopus ID: 2-s2.0-85190884720
FBXO5-mediated RNF183 degradation prevents endoplasmic reticulum stress-induced apoptosis and promotes colon cancer progression. (Ji J, Jing A, Ding Y, Ma X, Qian Q, Geng T, Cheng W, Zhang M, Sun Q, Ma S, Wang X, Yuan Q, Xu M, Qin J, Ma L, Yang J, He J, Du Q, Xia M, Xu Y, Chen Z, Zhu L, Liu W, Liu S, Liu B) Cell Death Dis 2024 Jan 11;15(1):33). PMID: 38212299; PMCID: PMC10784456; DOI: 10.1038/s41419-024-06421-2; Scopus ID: 2-s2.0-85182091692
FOXP4-mediated induction of PTK7 activates the Wnt/β-catenin pathway and promotes ovarian cancer development. (Ji J, Qian Q, Cheng W, Ye X, Jing A, Ma S, Ding Y, Ma X, Wang Y, Sun Q, Wang X, Chen Y, Zhu L, Yuan Q, Xu M, Qin J, Ma L, Yang J, Zhang M, Geng T, Wang S, Wang D, Song Y, Zhang B, Xu Y, Xu L, Liu S, Liu W, Liu B) Cell Death Dis 2024 May 13;15(5):332. PMID: 38740744; PMCID: PMC11091054; DOI: 10.1038/s41419-024-06713-7; Scopus ID: 2-s2.0-85192951272
Structure-Based Lead Optimization of Enterovirus D68 2A Protease Inhibitors. (Tan B, Liu C, Li K, Jadhav P, Lambrinidis G, Zhu L, Olson L, Tan H, Wen Y, Kolocouris A, Liu W, Wang J) J Med Chem 2023 Nov 09;66(21):14544-14563. PMID: 37857371; DOI: 10.1021/acs.jmedchem.3c00995; Scopus ID: 2-s2.0-85176509223
Cryo-EM structure of the human adenosine A2B receptor-Gs signaling complex. (Chen Y, Zhang J, Weng Y, Xu Y, Lu W, Liu W, Liu M, Hua T, Song G) Sci Adv 2022 Dec 23;8(51):eadd3709. PMID: 36563137; PMCID: PMC9788782; DOI: 10.1126/sciadv.add3709; Scopus ID: 2-s2.0-85144637416
An Isochroman Analog of CD3254 and Allyl-, Isochroman-Analogs of NEt-TMN Prove to Be More Potent Retinoid-X-Receptor (RXR) Selective Agonists Than Bexarotene. (Jurutka PW, di Martino O, Reshi S, Mallick S, Sausedo MA, Moen GA, Lee IJ, Ivan DJ, Krall TD, Peoples SJ, Perez A, Tromba L, Le A, Khadka I, Petros R, Savage BM, Salama E, Salama J, Ziller JW, Noh Y, Lee MY, Liu W, Welch JS, Marshall PA, Wagner CE) Int J Mol Sci 2022 Dec 19;23(24). PMID: 36555852; PMCID: PMC9782500; DOI: 10.3390/ijms232416213; Scopus ID: 2-s2.0-85144580245
Structural basis for receptor selectivity and inverse agonism in S1P5 receptors. (Lyapina E, Marin E, Gusach A, Orekhov P, Gerasimov A, Luginina A, Vakhrameev D, Ergasheva M, Kovaleva M, Khusainov G, Khorn P, Shevtsov M, Kovalev K, Bukhdruker S, Okhrimenko I, Popov P, Hu H, Weierstall U, Liu W, Cho Y, Gushchin I, Rogachev A, Bourenkov G, Park S, Park G, Hyun HJ, Park J, Gordeliy V, Borshchevskiy V, Mishin A, Cherezov V) Nat Commun 2022 Aug 12;13(1):4736. PMID: 35961984; PMCID: PMC9374744; DOI: 10.1038/s41467-022-32447-1; Scopus ID: 2-s2.0-85135832975
Structures of β1-adrenergic receptor in complex with Gs and ligands of different efficacies. (Su M, Paknejad N, Zhu L, Wang J, Do HN, Miao Y, Liu W, Hite RK, Huang XY) Nat Commun 2022 Jul 14;13(1):4095. PMID: 35835792; PMCID: PMC9283524; DOI: 10.1038/s41467-022-31823-1; Scopus ID: 2-s2.0-85134147752