Francis Peterson, PhD

Publications

• Fragment-based drug discovery of small molecule ligands for the human chemokine CCL28.

  (Zhou AL, Jensen DR, Peterson FC, Thomas MA, Schlimgen RR, Dwinell MB, Smith BC, Volkman BF.) SLAS Discov. 2023 Jun;28(4):163-169 PMID: 36841432 PMCID: PMC10339762 SCOPUS ID: 2-s2.0-85149845436 02/26/2023

• A modified ELISA assay differentiates CCL20 locked dimers from wild-type monomers.

  (Wu X, Clarke WR, Koplinski CA, Peterson FC, Dwinell MB, Wei G, Chao E, Huynh M, Yamada D, Volkman BF, Hwang ST.) J Immunol Methods. 2023 Apr;515:113453 PMID: 36863695 PMCID: PMC10715733 SCOPUS ID: 2-s2.0-85150034077 03/03/2023

• Mechanistic Insight into the Suppression of Polyglutamine Aggregation by SRCP1.

  (Haver HN, Wedemeyer M, Butcher E, Peterson FC, Volkman BF, Scaglione KM.) ACS Chem Biol. 2023 Mar 17;18(3):549-560 PMID: 36791332 PMCID: PMC10023506 SCOPUS ID: 2-s2.0-85148304370 02/16/2023

• De novo design of small beta barrel proteins.

  (Kim DE, Jensen DR, Feldman D, Tischer D, Saleem A, Chow CM, Li X, Carter L, Milles L, Nguyen H, Kang A, Bera AK, Peterson FC, Volkman BF, Ovchinnikov S, Baker D.) Proc Natl Acad Sci U S A. 2023 Mar 14;120(11):e2207974120 PMID: 36897987 PMCID: PMC10089152 SCOPUS ID: 2-s2.0-85150007162 03/11/2023

• NMR indicates the N-termini of PSGL1 and CCR7 bind competitively to the chemokine CCL21

  (Witt RN, Nickel KS, Binns JR, Gray AM, Hintz AM, Kofron NF, Steigleder SF, Peterson FC, Veldkamp CT.) Biochemistry and Biophysics Reports. September 2023;35 SCOPUS ID: 2-s2.0-85166176643 09/01/2023

• The Chemokine, CCL20, and Its Receptor, CCR6, in the Pathogenesis and Treatment of Psoriasis and Psoriatic Arthritis

  (Shi ZR, Mabuchi T, Riutta SJ, Wu X, Peterson FC, Volkman BF, Hwang ST.) Journal of Psoriasis and Psoriatic Arthritis. July 2023;8(3):107-117 SCOPUS ID: 2-s2.0-85150743226 07/01/2023

• Fragment-based screening by protein-detected NMR spectroscopy

  (Kerber PJ, Nuñez R, Jensen DR, Zhou AL, Peterson FC, Hill RB, Volkman BF, Smith BC.) Methods in Enzymology. January 2023;690:285-310 SCOPUS ID: 2-s2.0-85166280504 01/01/2023

• Structural studies of human fission protein FIS1 reveal a dynamic region important for GTPase DRP1 recruitment and mitochondrial fission.

  (Egner JM, Nolden KA, Harwig MC, Bonate RP, De Anda J, Tessmer MH, Noey EL, Ihenacho UK, Liu Z, Peterson FC, Wong GCL, Widlansky ME, Hill RB.) J Biol Chem. 2022 Dec;298(12):102620 PMID: 36272645 PMCID: PMC9747602 SCOPUS ID: 2-s2.0-85143990858 10/23/2022

• Selective and Cell-Active PBRM1 Bromodomain Inhibitors Discovered through NMR Fragment Screening.

  (Shishodia S, Nuñez R, Strohmier BP, Bursch KL, Goetz CJ, Olp MD, Jensen DR, Fenske TG, Ordonez-Rubiano SC, Blau ME, Roach MK, Peterson FC, Volkman BF, Dykhuizen EC, Smith BC.) J Med Chem. 2022 Oct 27;65(20):13714-13735 PMID: 36227159 PMCID: PMC9630929 SCOPUS ID: 2-s2.0-85140311972 10/14/2022

• Conformational selection guides β-arrestin recruitment at a biased G protein-coupled receptor.

  (Kleist AB, Jenjak S, Sente A, Laskowski LJ, Szpakowska M, Calkins MM, Anderson EI, McNally LM, Heukers R, Bobkov V, Peterson FC, Thomas MA, Chevigné A, Smit MJ, McCorvy JD, Babu MM, Volkman BF.) Science. 2022 Jul 08;377(6602):222-228 PMID: 35857540 PMCID: PMC9574477 SCOPUS ID: 2-s2.0-85133822505 07/21/2022

• Fluorinated triphenylphosphonium analogs improve cell selectivity and in vivo detection of mito-metformin

  (AbuEid M, Keyes RF, McAllister D, Peterson F, Kadamberi IP, Sprague DJ, Chaluvally-Raghavan P, Smith BC, Dwinell MB.) iScience. 22 December 2022;25(12) SCOPUS ID: 2-s2.0-85143723525 12/22/2022

• Conformational selection guides β-arrestin recruitment at a biased G protein–coupled receptor

  (Kleist AB, Jenjak S, Sente A, Laskowski LJ, Szpakowska M, Calkins MM, Anderson EI, McNally LM, Heukers R, Bobkov V, Peterson FC, Thomas MA, Chevigné A, Smit MJ, McCorvy JD, Babu MM, Volkman BF.) Science. 8 July 2022;377(6602):222-228 SCOPUS ID: 2-s2.0-85133822505 07/08/2022