Jieqing Zhu, PhD

Publications

• High-resolution mapping of the polyclonal immune response to the human platelet alloantigen HPA-1a (PlA1).

  (Zhi H, Ahlen MT, Thinn AMM, Weiler H, Curtis BR, Skogen B, Zhu J, Newman PJ.) Blood Adv. 2018 Nov 13;2(21):3001-3011 PMID: 30413435 PMCID: PMC6234362 SCOPUS ID: 2-s2.0-85067320916 11/11/2018

• Autonomous conformational regulation of β3 integrin and the conformation-dependent property of HPA-1a alloantibodies.

  (Thinn AMM, Wang Z, Zhou D, Zhao Y, Curtis BR, Zhu J.) Proc Natl Acad Sci U S A. 2018 Sep 25;115(39):E9105-E9114 PMID: 30209215 PMCID: PMC6166792 09/14/2018

• Structure of an extended β3 integrin.

  (Zhou D, Thinn AMM, Zhao Y, Wang Z, Zhu J.) Blood. 2018 Aug 30;132(9):962-972 PMID: 30018079 PMCID: PMC6117741 07/19/2018

• The membrane-distal regions of integrin α cytoplasmic domains contribute differently to integrin inside-out activation.

  (Thinn AMM, Wang Z, Zhu J.) Sci Rep. 2018 Mar 22;8(1):5067 PMID: 29568062 PMCID: PMC5864728 03/24/2018

• Csk/CD148 and platelet SFK activation: a balancing act!

  (Zhu J.) Blood. 2018 Mar 08;131(10):1042-1043 PMID: 29519930 PMCID: PMC5863704 03/10/2018

• A pivotal role for a conserved bulky residue at the α1-helix of the αI integrin domain in ligand binding.

  (Wang Z, Thinn AMM, Zhu J.) J Biol Chem. 2017 Dec 15;292(50):20756-20768 PMID: 29079572 PMCID: PMC5733610 10/29/2017

• Low-affinity binding in cis to P2Y2R mediates force-dependent integrin activation during hantavirus infection.

  (Bondu V, Wu C, Cao W, Simons PC, Gillette J, Zhu J, Erb L, Zhang XF, Buranda T.) Mol Biol Cell. 2017 Oct 15;28(21):2887-2903 PMID: 28835374 PMCID: PMC5638590 08/25/2017

• The importance of N-glycosylation on β3 integrin ligand binding and conformational regulation.

  (Cai X, Thinn AMM, Wang Z, Shan H, Zhu J.) Sci Rep. 2017 Jul 05;7(1):4656 PMID: 28680094 PMCID: PMC5498496 07/07/2017

• The Role of Sialylated Glycans in Human Platelet Endothelial Cell Adhesion Molecule 1 (PECAM-1)-mediated Trans Homophilic Interactions and Endothelial Cell Barrier Function.

  (Lertkiatmongkol P, Paddock C, Newman DK, Zhu J, Thomas MJ, Newman PJ.) J Biol Chem. 2016 Dec 09;291(50):26216-26225 PMID: 27793989 PMCID: PMC5207088 SCOPUS ID: 2-s2.0-85002858868 10/30/2016

• Antiendothelial αvβ3 Antibodies Are a Major Cause of Intracranial Bleeding in Fetal/Neonatal Alloimmune Thrombocytopenia.

  (Santoso S, Wihadmadyatami H, Bakchoul T, Werth S, Al-Fakhri N, Bein G, Kiefel V, Zhu J, Newman PJ, Bayat B, Sachs UJ.) Arterioscler Thromb Vasc Biol. 2016 Aug;36(8):1517-24 PMID: 27283740 PMCID: PMC5140275 SCOPUS ID: 2-s2.0-84973532000 06/11/2016

• Structural basis for PECAM-1 homophilic binding.

  (Paddock C, Zhou D, Lertkiatmongkol P, Newman PJ, Zhu J.) Blood. 2016 Feb 25;127(8):1052-61 PMID: 26702061 PMCID: PMC4768429 SCOPUS ID: 2-s2.0-84960356253 12/25/2015

• Platelet Activation and Thrombus Formation over IgG Immune Complexes Requires Integrin αIIbβ3 and Lyn Kinase.

  (Zhi H, Dai J, Liu J, Zhu J, Newman DK, Gao C, Newman PJ.) PLoS One. 2015;10(8):e0135738 PMID: 26291522 PMCID: PMC4546160 SCOPUS ID: 2-s2.0-84942901879 08/21/2015