Michael Widlansky Lab

Michael E. Widlansky, MD, MPH
Professor, Department of Medicine
Principal Investigator
mwidlans@mcw.edu

The Widlansky laboratory work is currently focused on the roles of mircroRNA-29, mitochondrial fission proteins, and the microbiome in the regulation of human vascular endothelial function. It also focuses on studying novel mechanisms of vascular dysfunction in diabetes. His work tests these novel mechanistic insights to determine their relevance to human vascular pathophysiology. In addition, the Widlansky laboratory studies the impact of dietary, pharmacological, and exercise-based interventions on vascular function persons with and without disease. The laboratory also has formed a human vascular research core to foster collaboration with investigators from other disciplines interested in the impact of vascular function on disease states relevant to their fields of interest.

Meet Our Team

Amberly Anger

Program Manager I

aanger@mcw.edu

Nabeel Khan, MD

Assistant Professor; Cardiology Medicine Research Fellow

Jingli Wang, MD, PhD

Research Scientist II

jiwang@mcw.edu

(414) 456-6777

Justin Westhoff

Research Technologist I

jwesthoff@mcw.edu

(414) 955-7436

Rong Ying, MD

Research Technologist II

riying@mcw.edu

(414) 456-7436

Alumni/Former Trainees

Benjamin Hofeld
Mobin Malik
V. K. Puppala
Tisha Suboc
Mike Tanner
Sudhi Tyagi

Role of the circulating milieu in age-related arterial dysfunction: a novel ex vivo approach.

(Mahoney SA, VanDongen NS, Greenberg NT, Venkatasubramanian R, Rossman MJ, Widlansky ME, Brunt VE, Bernaldo de Quirós Y, Seals DR, Clayton ZS.) Am J Physiol Heart Circ Physiol. 2024 May 01;326(5):H1279-H1290 PMID: 38517225 PMCID: PMC11380963 SCOPUS ID: 2-s2.0-85191614683 03/22/2024
Proteomic Profiles of Human Arterioles Isolated From Fresh Adipose Tissue or Following Overnight Storage.

(Pandey R, Roberts ML, Wang J, Pereckas M, Jensen D, Greene AS, Widlansky ME, Liang M.) Lab Invest. 2024 May;104(5):102036 PMID: 38408704 PMCID: PMC11098693 SCOPUS ID: 2-s2.0-85189472781 02/27/2024
Clinical Implications of COVID-19-Related Endothelial Dysfunction

(Aljadah M, Khan N, Beyer AM, Chen Y, Blanker A, Widlansky ME.) JACC: Advances. August 2024;3(8) SCOPUS ID: 2-s2.0-85197318304 08/01/2024
Coronary Plaque Sampling Reveals Molecular Insights Into Coronary Artery Disease.

(Widlansky ME, Liu Y, Tumusiime S, Hofeld B, Khan N, Aljadah M, Wang J, Anger A, Qiu Q, Therani B, Liu P, Liang M.) Circ Res. 2023 Sep;133(6):532-534 PMID: 37539553 PMCID: PMC10467803 SCOPUS ID: 2-s2.0-85169502007 08/04/2023
Degenerative Mitral Stenosis: A Case-Based Review.

(Lamberg M, Devine A, Jewulski J, Smith A, Garster N, Sharma A, Mason PJ, Lewandowski D, Widlansky M, Mohananey D.) CASE (Phila). 2023 May;7(5):189-196 PMID: 37325463 PMCID: PMC10264206 06/16/2023
17β-Estradiol promotes sex-specific dysfunction in isolated human arterioles.

(SenthilKumar G, Katunaric B, Bordas-Murphy H, Young M, Doren EL, Schulz ME, Widlansky ME, Freed JK.) Am J Physiol Heart Circ Physiol. 2023 Mar 01;324(3):H330-H337 PMID: 36607795 PMCID: PMC9925162 SCOPUS ID: 2-s2.0-85147536237 01/07/2023
Finding Needles in the Gut Microbiota's Haystack.

(Aljadah M, Widlansky ME.) Circ Res. 2023 Jan 20;132(2):182-184 PMID: 36656969 PMCID: PMC9869460 SCOPUS ID: 2-s2.0-85146623682 01/20/2023
Structural studies of human fission protein FIS1 reveal a dynamic region important for GTPase DRP1 recruitment and mitochondrial fission.

(Egner JM, Nolden KA, Harwig MC, Bonate RP, De Anda J, Tessmer MH, Noey EL, Ihenacho UK, Liu Z, Peterson FC, Wong GCL, Widlansky ME, Hill RB.) J Biol Chem. 2022 Dec;298(12):102620 PMID: 36272645 PMCID: PMC9747602 SCOPUS ID: 2-s2.0-85143990858 10/23/2022
Onset of the COVID-19 pandemic reduced active time in patients with implanted cardiac devices.

(Sommers N, Berger M, Rubenstein JC, Roth J, Pan A, Thompson C, Widlansky ME.) Eur Rev Aging Phys Act. 2022 Nov 02;19(1):26 PMID: 36324065 PMCID: PMC9628136 SCOPUS ID: 2-s2.0-85141077708 11/04/2022
Broad-acting therapeutic effects of miR-29b-chitosan on hypertension and diabetic complications.

(Jensen DM, Han P, Mangala LS, Lopez-Berestein G, Sood AK, Liu J, Kriegel AJ, Usa K, Widlansky ME, Liang M.) Mol Ther. 2022 Nov 02;30(11):3462-3476 PMID: 35965413 PMCID: PMC9637778 SCOPUS ID: 2-s2.0-85136662053 08/16/2022
Novel DNM1L variants impair mitochondrial dynamics through divergent mechanisms.

(Nolden KA, Egner JM, Collier JJ, Russell OM, Alston CL, Harwig MC, Widlansky ME, Sasorith S, Barbosa IA, Douglas AG, Baptista J, Walker M, Donnelly DE, Morris AA, Tan HJ, Kurian MA, Gorman K, Mordekar S, Deshpande C, Samanta R, McFarland R, Hill RB, Taylor RW, Oláhová M.) Life Sci Alliance. 2022 Aug 01;5(12) PMID: 35914810 PMCID: PMC9354038 SCOPUS ID: 2-s2.0-85135355811 08/02/2022
Acute effects of singing on cardiovascular biomarkers.

(Somayaji K, Frenkel M, Tabaza L, Visotcky A, Ruck TK, Ofori EK, Widlansky ME, Kulinski J.) Front Cardiovasc Med. 2022;9:869104 PMID: 35924212 PMCID: PMC9339901 SCOPUS ID: 2-s2.0-85135257452 08/05/2022