Medical College of Wisconsin
Medical College of Wisconsin Medical College of Wisconsin
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Cell Biology, Neurobiology and Anatomy (CBNA)
Jonathan-Marchant

Jonathan S. Marchant, MA, PhD

Marcus Professor & Chair

Locations

  • Cell Biology, Neurobiology & Anatomy, BSB4

Contact Information

Education

PhD, Pharmacology, Cambridge University
Postdoctoral, Neurobiology & Behavior, UC Irvine, CA

Biography

Dr. Marchant received his PhD in Pharmacology from the University of Cambridge in the laboratory of Colin Taylor, and then performed post-doctoral training as a Wellcome Trust Training Fellow in Ian Parker’s laboratory in the Department of Neurobiology and Behavior at the University of California-Irvine. He was a Faculty Member in the Department of Pharmacology at the University of Minnesota from 2002-2017, until joining MCW as the Marcus Chair of Cell Biology, Neurobiology and Anatomy in 2017.

In a groundbreaking study, Dr. Marchant and his team identified a new class of compounds called benzamidoquinazolinones (BZQs) that show promise as broad-spectrum treatments for trematode infections in humans.

Read the full story

Research Areas of Interest

  • Antiparasitic Agents
  • Calcium Channels
  • Calcium Signaling
  • Endoplasmic Reticulum
  • Endosomes
  • Ion Channels
  • Lysosomes
  • Schistosomiasis

Research Experience

  • Fluorescent Dyes
  • Gene Silencing
  • High-Throughput Screening Assays
  • Membrane Proteins
  • Microinjections
  • Microscopy, Confocal
  • Planarians
  • RNA Interference
  • Signal Transduction

Research Interests

We are interested in the how cells respond to stimulation. Our focus is on signal transduction through Ca2+ signaling. Indeed, it is hard to think of any cellular process that is not regulated by Ca2+. Ca2+ signals can result from activation of intracellular Ca2+ channels and dysfunction of these same Ca2+ channels are involved in neurodegenerative disease and cancer. To appreciate how cell functions are controlled by Ca2+ signals, and how pathological cues subvert their function, we must understand how the distribution and the regulatory properties of intracellular Ca2+ channels control the genesis of Ca2+ signals.

Publications

Publications of Jonathan S. Marchant PhD from the Faculty Collaboration Database