Medical College of Wisconsin
Medical College of Wisconsin Medical College of Wisconsin
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Cell Biology, Neurobiology and Anatomy (CBNA)
Olena Isaeva, PhD

Olena Isaeva, PhD

Assistant Professor

Locations

  • Cell Biology, Neurobiology & Anatomy
    BSB4

Contact Information

Education

PhD and DSc, Bogomoletz Institute of Physiology, Kyiv, Ukraine
Postdoctoral, Rutgers New Jersey Medical School, Newark, NJ
Postdoctoral, Geisel School of Medicine at Dartmouth, Hanover, NH

Biography

Dr. Isaeva earned her PhD in Physiology at the Bogomoletz Institute of Physiology in Kyiv Ukraine. She had postdoctoral training in Dr. Natalia Shirokova’s laboratory in Rutgers New Jersey Medical School and the laboratory of Dr. Gregory L Holmes at Geisel School of Medicine at Dartmouth. In 2018 Dr. Isaeva joined the Physiology Department in Medical College of Wisconsin as Visiting Assistant Professor. She continues her career in the Department of Cell Biology, Neurobiology, and Anatomy, where she was promoted to Assistant Professor in 2021.

Research Areas of Interest

  • Ion Channels
  • Calcium Signaling
  • Neuropathic Pain
  • Epilepsy research
  • Synaptic Physiology and Plasticity
  • Behavioral Neuroscience

Methodologies and Techniques

  • Single-Channel and Whole-Cell Patch Clamp
  • Field Potential and Synaptic Plasticity
  • EEG in Rodents
  • Microscopy, Confocal
  • Animal Behavior
  • Cell Culture
  • Immunolabeling
  • Auditory Brain Response
  • Transepithelial Current Measurement

Research Areas of Interest

  • Calcium Signaling
  • Epilepsy
  • Hearing Disorders
  • Hippocampus
  • Hypertension
  • Ion Channels
  • Kidney
  • Pain
  • Sensation Disorders

Research Experience

  • Behavior, Animal
  • Electroencephalography
  • Functional Neuroimaging
  • Hearing Tests
  • Patch-Clamp Techniques

Research Interests

Dr. Isaeva has broad expertise in cell biology, biophysics, neuroscience, and renal physiology. Her main research interests are focused on the study of biophysical and pharmacological properties of ion channels in neuronal and epithelial cells. Ion channels play a critical physiological role in the regulation of cellular homeostasis, ion transport, and signal transduction. Moreover, many human diseases are linked to ion channel malfunctions. So, understanding their specific role and complex interaction of ion channels with extra- and intracellular signaling cascades in the development and progression of pathophysiological processes is important for new drug design and efficient therapy. For many years Dr. Isaeva studies were focused on the role of ligand- and voltage-gated ion channels in the cellular and network mechanisms underlying the disturbance of the physiological patterns of neuronal activity in the central nervous system by brain insults or genetic disorders. In Dr. Cheryl Stucky laboratory Dr. Isaeva focuses her studies on the cellular and molecular mechanisms that underlie mechanical sensitization and pain.

Publications

Publications of Olena Isaeva PhD from the Faculty Collaboration Database