Ashraf El-Meanawy, MD, MS, PhD, FASN

Publications

• Kidney Injury by Unilateral Ureteral Obstruction in Mice Lacks Sex Differences.

  (Goorani S, Khan AH, Mishra A, El-Meanawy A, Imig JD.) Kidney Blood Press Res. 2024;49(1):69-80 PMID: 38185105 PMCID: PMC10877550 SCOPUS ID: 2-s2.0-85184302998 01/08/2024

• Impact of Finerenone-Induced Albuminuria Reduction on Chronic Kidney Disease Outcomes in Type 2 Diabetes : A Mediation Analysis.

  (Agarwal R, Tu W, Farjat AE, Farag YMK, Toto R, Kaul S, Lawatscheck R, Rohwedder K, Ruilope LM, Rossing P, Pitt B, Filippatos G, Anker SD, Bakris GL, FIDELIO-DKD and FIGARO-DKD Investigators.) Ann Intern Med. 2023 Dec;176(12):1606-1616 PMID: 38048573 12/04/2023

• Erratum. Finerenone in Patients With Chronic Kidney Disease and Type 2 Diabetes According to Baseline HbA1c and Insulin Use: An Analysis From the FIDELIO-DKD Study. Diabetes Care 2022;45:888-897.

  (Rossing P, Burgess E, Agarwal R, Anker SD, Filippatos G, Pitt B, Ruilope LM, Gillard P, MacIsaac RJ, Wainstein J, Joseph A, Brinker M, Roessig L, Scott C, Bakris GL, FIDELIO-DKD Investigators .) Diabetes Care. 2023 Sep 01;46(9):1721 PMID: 37310695 PMCID: PMC10465986 06/13/2023

• Outcomes with Finerenone in Participants with Stage 4 CKD and Type 2 Diabetes: A FIDELITY Subgroup Analysis.

  (Sarafidis P, Agarwal R, Pitt B, Wanner C, Filippatos G, Boletis J, Tuttle KR, Ruilope LM, Rossing P, Toto R, Anker SD, Liu ZH, Joseph A, Ahlers C, Brinker M, Lawatscheck R, Bakris G, FIDELIO-DKD and FIGARO-DKD Investigators.) Clin J Am Soc Nephrol. 2023 May 01;18(5):602-612 PMID: 36927680 PMCID: PMC10278789 03/18/2023

• Salt-sensitive hypertension after reversal of unilateral ureteral obstruction.

  (Imig JD, Khan MAH, Stavniichuk A, Jankiewicz WK, Goorani S, Yeboah MM, El-Meanawy A.) Biochem Pharmacol. 2023 Apr;210:115438 PMID: 36716827 PMCID: PMC10107073 SCOPUS ID: 2-s2.0-85148360442 01/31/2023

• Finerenone in Patients With Chronic Kidney Disease and Type 2 Diabetes by Sodium-Glucose Cotransporter 2 Inhibitor Treatment: The FIDELITY Analysis.

  (Rossing P, Anker SD, Filippatos G, Pitt B, Ruilope LM, Birkenfeld AL, McGill JB, Rosas SE, Joseph A, Gebel M, Roberts L, Scheerer MF, Bakris GL, Agarwal R, FIDELIO-DKD and FIGARO-DKD Investigators.) Diabetes Care. 2022 Dec 01;45(12):2991-2998 PMID: 35972218 PMCID: PMC9862372 08/17/2022

• Lack of xanthine dehydrogenase leads to a remarkable renal decline in a novel hypouricemic rat model.

  (Dissanayake LV, Zietara A, Levchenko V, Spires DR, Burgos Angulo M, El-Meanawy A, Geurts AM, Dwinell MR, Palygin O, Staruschenko A.) iScience. 2022 Sep 16;25(9):104887 PMID: 36039296 PMCID: PMC9418856 08/31/2022

• Accelerated lysine metabolism conveys kidney protection in salt-sensitive hypertension.

  (Rinschen MM, Palygin O, El-Meanawy A, Domingo-Almenara X, Palermo A, Dissanayake LV, Golosova D, Schafroth MA, Guijas C, Demir F, Jaegers J, Gliozzi ML, Xue J, Hoehne M, Benzing T, Kok BP, Saez E, Bleich M, Himmerkus N, Weisz OA, Cravatt BF, Krüger M, Benton HP, Siuzdak G, Staruschenko A.) Nat Commun. 2022 Jul 14;13(1):4099 PMID: 35835746 PMCID: PMC9283537 SCOPUS ID: 2-s2.0-85134142317 07/15/2022

• Finerenone in Patients With Chronic Kidney Disease and Type 2 Diabetes According to Baseline HbA1c and Insulin Use: An Analysis From the FIDELIO-DKD Study.

  (Rossing P, Burgess E, Agarwal R, Anker SD, Filippatos G, Pitt B, Ruilope LM, Gillard P, MacIsaac RJ, Wainstein J, Joseph A, Brinker M, Roessig L, Scott C, Bakris GL, FIDELIO-DKD Investigators.) Diabetes Care. 2022 Apr 01;45(4):888-897 PMID: 35061867 PMCID: PMC9271031 01/22/2022

• Lack of xanthine dehydrogenase leads to a remarkable renal decline in a novel hypouricemic rat model

  (Dissanayake LV, Zietara A, Levchenko V, Spires DR, Burgos Angulo M, El-Meanawy A, Geurts AM, Dwinell MR, Palygin O, Staruschenko A.) iScience. 16 September 2022;25(9) SCOPUS ID: 2-s2.0-85136236916 09/16/2022

• p66Shc-mediated hydrogen peroxide production impairs nephrogenesis causing reduction of number of glomeruli.

  (Miller B, Palygin O, El-Meanawy A, Mattson DL, Geurts AM, Staruschenko A, Sorokin A.) Life Sci. 2021 Aug 15;279:119661 PMID: 34087282 PMCID: PMC8265215 SCOPUS ID: 2-s2.0-85107260373 06/05/2021

• Long-term kidney function and survival in recipients of allografts from living kidney donors with hypertension: a national cohort study.

  (Al Ammary F, Yu S, Muzaale AD, Segev DL, Liyanage L, Crews DC, Brennan DC, El-Meanawy A, Alqahtani S, Atta MG, Levan ML, Caffo BS, Welling PA, Massie AB.) Transpl Int. 2021 Aug;34(8):1530-1541 PMID: 34129713 SCOPUS ID: 2-s2.0-85109388213 06/16/2021