Matthew C. Surdel, PhD

Assistant Professor, Medicine (Infectious Diseases); Center for Infectious Disease Research

Locations

Center for Infectious Disease Research
8701 Watertown Plank Rd.
TBRC C3920
Milwaukee WI 53226

Contact Information

Education

BS, Biochemistry, Davidson College, Davidson, NC
PhD, Pathology, Microbiology & Immunology, Vanderbilt University School of Medicine, Nashville, TN

Research Interests

The Surdel laboratory focuses on pathogenic Leptospira species, which are gram-negative spirochetes and the causative agents of leptospirosis. Leptospirosis is a potentially fatal zoonosis that disproportionately affects resource-poor parts of the world. The goal of the Surdel laboratory is to identify and define the mechanisms that pathogenic bacteria utilize to bind host cells and ligands. This work will provide novel insight into the ability of Leptospira to colonize and cause disease within the host, and ultimately help guide the development of novel therapeutics and vaccines.

Leptospiral adhesins: from identification to future perspectives.

(Surdel MC, Coburn J.) Front Microbiol. 2024;15:1458655 PMID: 39206373 PMCID: PMC11350617 08/31/2024
Identification of amino acid domains of Borrelia burgdorferi P66 that are surface exposed and important for localization, oligomerization, and porin function of the protein.

(Curtis MW, Fierros CH, Hahn BL, Surdel MC, Kessler J, Anderson PN, Vandewalle-Capo M, Bonde M, Zhu J, Bergström S, Coburn J.) Front Cell Infect Microbiol. 2022;12:991689 PMID: 36211976 PMCID: PMC9539438 SCOPUS ID: 2-s2.0-85139437187 10/11/2022
Heterologous production of the adhesin LIC13411 from pathogenic Leptospira facilitates binding of non-pathogenic Leptospira in vitro and in vivo.

(Surdel MC, Hahn BL, Anderson PN, Coburn J.) Front Cell Infect Microbiol. 2022;12:917963 PMID: 35937702 PMCID: PMC9354625 SCOPUS ID: 2-s2.0-85135274644 08/09/2022
Hematogenous dissemination of pathogenic and non-pathogenic Leptospira in a short-term murine model of infection.

(Surdel MC, Anderson PN, Hahn BL, Coburn J.) Front Cell Infect Microbiol. 2022;12:917962 PMID: 35923802 PMCID: PMC9339599 SCOPUS ID: 2-s2.0-85135250975 08/05/2022
Antibacterial photosensitization through activation of coproporphyrinogen oxidase.

(Surdel MC, Horvath DJ Jr, Lojek LJ, Fullen AR, Simpson J, Dutter BF, Salleng KJ, Ford JB, Jenkins JL, Nagarajan R, Teixeira PL, Albertolle M, Georgiev IS, Jansen ED, Sulikowski GA, Lacy DB, Dailey HA, Skaar EP.) Proc Natl Acad Sci U S A. 2017 Aug 08;114(32):E6652-E6659 PMID: 28739897 PMCID: PMC5559000 SCOPUS ID: 2-s2.0-85026874355 07/26/2017
Bacterial Nitric Oxide Synthase Is Required for the Staphylococcus aureus Response to Heme Stress.

(Surdel MC, Dutter BF, Sulikowski GA, Skaar EP.) ACS Infect Dis. 2016 Aug 12;2(8):572-8 PMID: 27626297 PMCID: PMC6610873 SCOPUS ID: 2-s2.0-85006198864 09/15/2016
Correction: Coronaviruses Lacking Exoribonuclease Activity Are Susceptible to Lethal Mutagenesis: Evidence for Proofreading and Potential Therapeutics

(Surdel MC.) PLoS Pathogens. July 2014;10(7) SCOPUS ID: 2-s2.0-84905394229 01/01/2014
Coronaviruses lacking exoribonuclease activity are susceptible to lethal mutagenesis: evidence for proofreading and potential therapeutics.

(Smith EC, Blanc H, Surdel MC, Vignuzzi M, Denison MR.) PLoS Pathog. 2013 Aug;9(8):e1003565 PMID: 23966862 PMCID: PMC3744431 08/24/2013