Michelle Riehle, PhD

Associate Professor

Locations

Microbiology & Immunology
BSB B2920

Contact Information

Education

PhD, Ecology and Evolutionary Biology, University of California, Irvine, CA 2003

Learn more about the Riehle Lab

Research Experience

Anopheles
Evolution, Molecular
Genetic Variation
Host-Parasite Interactions
Immunity, Innate
Insect Vectors
Malaria, Falciparum

Educational Expertise

Evolution, Molecular
Genetics
Microbiology

Research Interests

Our main areas of scientific investigation revolve around understanding differential susceptibility to infection with malaria parasites in the mosquito vector population.

We are taking an approach grounded in genetics to understand how natural variation affects a mosquito’s ability to be infected with Plasmodium parasites. Our current focus is on querying the non-coding genome; specifically enhancers, small RNAs and long non-coding RNAs. We complement our genetics approaches with functional investigations employing microbiological, biochemical, cell biological and molecular biology approaches.

We are also interested in how the prokaryotic and micro eukaryotic members of the mosquito microbiome influence to the mosquito immune response and how specific bacterial or microeukaryotic taxa affect mosquito gene expression and the innate immune response to infection with Plasmodium falciparum.

All of our work leverages approaches across many scientific disciplines including genetics, molecular biology, microbiology, cell biology, and computational biology to address important outstanding questions in malaria transmission and human health.

Molecular characterization and genetic authentication assay for Anopheles 'hemocyte-like' cell lines 4a-3A and 4a-3B.

(Eggleston H, Njoya K, Anderson CE, Holm I, Eiglmeier K, Liang J, Sharakhov IV, Vernick KD, Riehle MM.) Parasit Vectors. 2022 Dec 13;15(1):465 PMID: 36514125 PMCID: PMC9749150 SCOPUS ID: 2-s2.0-85143791043 12/14/2022
Genetics and immunity of Anopheles response to the entomopathogenic fungus Metarhizium anisopliae overlap with immunity to Plasmodium.

(Bukhari T, Aimanianda V, Bischoff E, Brito-Fravallo E, Eiglmeier K, Riehle MM, Vernick KD, Mitri C.) Sci Rep. 2022 Apr 15;12(1):6315 PMID: 35428783 PMCID: PMC9012835 SCOPUS ID: 2-s2.0-85128387936 04/17/2022
Publisher Correction: Anopheles ecology, genetics and malaria transmission in northern Cambodia.

(Vantaux A, Riehle MM, Piv E, Farley EJ, Chy S, Kim S, Corbett AG, Fehrman RL, Pepey A, Eiglmeier K, Lek D, Siv S, Mueller I, Vernick KD, Witkowski B.) Sci Rep. 2021 Jun 09;11(1):12553 PMID: 34108534 PMCID: PMC8190266 SCOPUS ID: 2-s2.0-85107408524 06/11/2021
Anopheles ecology, genetics and malaria transmission in northern Cambodia.

(Vantaux A, Riehle MM, Piv E, Farley EJ, Chy S, Kim S, Corbett AG, Fehrman RL, Pepey A, Eiglmeier K, Lek D, Siv S, Mueller I, Vernick KD, Witkowski B.) Sci Rep. 2021 Mar 19;11(1):6458 PMID: 33742030 PMCID: PMC7979810 SCOPUS ID: 2-s2.0-85102850695 03/21/2021
Discovery of Ongoing Selective Sweeps within Anopheles Mosquito Populations Using Deep Learning.

(Xue AT, Schrider DR, Kern AD, Ag1000g Consortium.) Mol Biol Evol. 2021 Mar 09;38(3):1168-1183 PMID: 33022051 PMCID: PMC7947845 SCOPUS ID: 2-s2.0-85102911117 10/07/2020
Filtering the Junk: Assigning Function to the Mosquito Non-Coding Genome.

(Farley EJ, Eggleston H, Riehle MM.) Insects. 2021 Feb 22;12(2) PMID: 33671692 PMCID: PMC7926655 03/07/2021
Comprehensive Genomic Discovery of Non-Coding Transcriptional Enhancers in the African Malaria Vector Anopheles coluzzii.

(Holm I, Nardini L, Pain A, Bischoff E, Anderson CE, Zongo S, Guelbeogo WM, Sagnon N, Gohl DM, Nowling RJ, Vernick KD, Riehle MM.) Front Genet. 2021;12:785934 PMID: 35082832 PMCID: PMC8784733 01/28/2022
Anopheles ecology, genetics and malaria transmission in northern Cambodia

(Vantaux A, Riehle MM, Piv E, Farley EJ, Chy S, Kim S, Corbett AG, Fehrman RL, Pepey A, Eiglmeier K, Lek D, Siv S, Mueller I, Vernick KD, Witkowski B.) Scientific Reports. December 2021;11(1) SCOPUS ID: 2-s2.0-85102850695 12/01/2021
Publisher Correction: Anopheles ecology, genetics and malaria transmission in northern Cambodia (Scientific Reports, (2021), 11, 1, (6458), 10.1038/s41598-021-85628-1)

(Vantaux A, Riehle MM, Piv E, Farley EJ, Chy S, Kim S, Corbett AG, Fehrman RL, Pepey A, Eiglmeier K, Lek D, Siv S, Mueller I, Vernick KD, Witkowski B.) Scientific Reports. December 2021;11(1) SCOPUS ID: 2-s2.0-85107408524 12/01/2021
Comprehensive Ecological and Geographic Characterization of Eukaryotic and Prokaryotic Microbiomes in African Anopheles.

(Cuesta EB, Coulibaly B, Bukhari T, Eiglmeier K, Kone R, Coulibaly MB, Zongo S, Barry M, Gneme A, Guelbeogo WM, Beavogui AH, Traore SF, Sagnon N, Vernick KD, Riehle MM.) Front Microbiol. 2021;12:635772 PMID: 34054746 PMCID: PMC8153677 06/01/2021
Resistance to pirimiphos-methyl in West African Anopheles is spreading via duplication and introgression of the Ace1 locus

(Grau-Bové X, Lucas E, Pipini D, Rippon E, van ‘t Hof AE, Constant E, Dadzie S, Egyir-Yawson A, Essandoh J, Chabi J, Djogbénou L, Harding NJ, Miles A, Kwiatkowski DP, Donnelly MJ, Weetman D, Amaya-Romero JE, Ayala D, Battey CJ, Bejon P, Besansky NJ, Burt A, Cano J, Caputo B, Constant E, Costantini C, Coulibaly B, della Torre A, Diabaté A, Dinis J, Donnelly MJ, Drury E, Edouardo J, Elissa N, Essandoh J, Fontaine MC, Godfray CHJ, Hahn MW, Harding NJ, Henrichs C, Hubbart C, Isaacs AT, Jawara M, Jeffreys AE, Jyothi D, Kamali M, Kern AD, Clarkson CS, Lawniczak MKN, Le Goff G, Lucas E, Malangone C, Mawejje HD, Mbogo C, Mead D, Midega J, Miles A, Nwakanma DC, O’Loughlin S, Pinto J, Riehle MM, Robert V, Rockett KA, Rohatgi KR, Rowlands K, Schrider DR, Sharakhov I, Simpson V, Stalker J, Troco AD, Vernick KD, Weetman D, Bradley J.) PLoS Genetics. 21 January 2021;17(1) SCOPUS ID: 2-s2.0-85099805834 01/21/2021
Genome variation and population structure among 1142 mosquitoes of the African malaria vector species Anopheles gambiae and Anopheles coluzzii.

(Anopheles gambiae 1000 Genomes Consortium.) Genome Res. 2020 Oct;30(10):1533-1546 PMID: 32989001 PMCID: PMC7605271 SCOPUS ID: 2-s2.0-85092682445 09/30/2020