Kathleen M. Bone, PhD, DABMGG, FCCMG, FACMG

Associate Professor

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Locations

Pathology - Froedtert Hospital

Specialties

Clinical Cytogenetics
Molecular Cytogenetics
Clinical Molecular Genetics
Laboratory Genetics and Genomics

Languages

English

Education

PhD
DABMGG-Diplomate of the American Board of Genetics and Genomics
FCCMG-Fellow of the Canadian College of Medical Geneticists
FACMG-Fellow of the American College of Medical Genetics and Genomics

Biography

Dr. Bone's primary clinical activity as the Medical Director of Cytogenetics includes review, interpretation and reporting of cytogenetic cases and results, as well as providing technical and clinical support to laboratory technologists and referring physicians. She is also involved in medical student and pathology resident and fellow teaching.

Clinical Expertise

Chromosome Aberrations
Chromosomes, Human
Cytogenetic Analysis
Cytogenetics
DNA
DNA Mismatch Repair
DNA Repair
Genetic Services
Genetic Techniques
Genetic Testing
Genetics
Genetics, Medical

Research Interests

Characterization of complex constitutional and acquired hematological and acquired chromosomal arrangements

Chromosomal instability and tumorigenic potential

A multicenter analysis of individuals with a 47,XXY/46,XX karyotype.

(Guess T, Wheeler FC, Yenamandra A, Schilit SLP, Anderson HS, Bone KM, Carstens B, Conlin L, Dulik MC, Dupont BR, Fanning E, Gardner JA, Haag M, Hilton BA, Johnson J, Kogan J, Murry J, Polonis K, Quigley DI, Repnikova EA, Rowsey RA, Spinner N, Stoeker M, Thurston V, Wiley M, Zhang L.) Genet Med. 2024 Oct;26(10):101212 PMID: 39011769 SCOPUS ID: 2-s2.0-85202569940 07/16/2024
Fate control engagement augments NK cell responses in LV/hu-IL-12 transduced sarcoma.

(Rademacher MJ, Faber ML, Bone KM, Medin JA, Schloemer NJ.) Exp Mol Pathol. 2024 Jun;137:104898 PMID: 38729059 SCOPUS ID: 2-s2.0-85192295267 05/11/2024
Detection of chromosomal alteration after infusion of gene-edited allogeneic CAR T cells.

(Sasu BJ, Opiteck GJ, Gopalakrishnan S, Kaimal V, Furmanak T, Huang D, Goswami A, He Y, Chen J, Nguyen A, Balakumaran A, Shah NN, Hamadani M, Bone KM, Prashad S, Bowen MA, Pertel T, Embree HD, Gidwani SG, Chang D, Moore A, Leonard M, Amado RG.) Mol Ther. 2023 Mar 01;31(3):676-685 PMID: 36518079 PMCID: PMC10014221 SCOPUS ID: 2-s2.0-85145741279 12/16/2022
Chapter: Ring Chromosome 4.

(Bone, KM, Chernos, J, Thomas, MA.) Human Ring Chromosomes: A practical guide for clinicians and families. Part II Constitutional Ring Chromosomes.. In review. 03/30/2023
Atypical Presentation in Sclerosing Epithelioid Fibrosarcoma: A Case Report

(Miller LJ, Saterbak A, Parsons LN, Singh R, Bone KM..) AJCP. 9 Nov 2022; 158 (Supplement_1):S38-S39:doi: 10.1093/ajcp/aqac126.072 11/09/2022
Effects of EWSR1 Amplification on the Clinical and Histologic Behavior of Non-Ewing Sarcoma Soft Tissue Tumors

(Miller LJ, Bodnar C, Parsons LN, Singh R, Bone KM..) JMD [Internet]. 2022 Oct. 24(10, Supplement) S1-S154.doi: 10.1016/S1525-1578(22)00284-7 10/24/2022
Pediatric Donor Cell Acute Lymphoblastic Leukemia Following Bone Marrow Transplant for GATA2 Mutation.

(Scheuermann A, Moskop A, Hopp A, Bone K, Drendel HM, Talano J, Harker-Murray P, Astle J.) J Pediatr Hematol Oncol. 2022 Jul 01;44(5):268-270 PMID: 35235548 SCOPUS ID: 2-s2.0-85129146818 03/03/2022
It Takes a Village: Providing International Pediatric Pathology Services in a Resource-Limited Setting.

(Hopp AM, Tetzlaff JE, Kopidlansky K, Leventaki V, Parsons LN, Bone K, Drendel HM, Sreynich K, Lyvannak S, Heng S, Chanpheaktra N, Putchhat H, Khauv P, Camitta BM, Jarzembowski JA.) Am J Clin Pathol. 2022 Jul 01;158(1):81-95 PMID: 35050350 SCOPUS ID: 2-s2.0-85133980519 01/21/2022
Correction: Parashar et al. Patient-Derived Ovarian Cancer Spheroids Rely on PI3K-AKT Signaling Addiction for Cancer Stemness and Chemoresistance. Cancers 2022, 14, 958.

(Parashar D, Geethadevi A, Mittal S, McAlarnen LA, George J, Kadamberi IP, Gupta P, Uyar DS, Hopp EE, Drendel H, Bishop EA, Bradley WH, Bone KM, Rader JS, Pradeep S, Chaluvally-Raghavan P.) Cancers (Basel). 2022 May 16;14(10) PMID: 35626175 PMCID: PMC9140135 05/29/2022
Parashar D, Geethadevi A, Mittal S, McAlarnen LA, George J, Kadamberi IP, Gupta P, Uyar DS, Hopp EE, Drendel H, Bishop EA, Bradley WH, Bone KM, Rader JS, Pradeep S, Chaluvally-Raghavan P.

(Correction: Parashar et al. Patient-Derived Ovarian Cancer Spheroids Rely on PI3K-AKT Signaling Addiction for Cancer Stemness and Chemoresistance.) Cancers (Basel). 2022 May 16;14(10):2443. PMCID: PMC9140135 05/16/2022
A complex KMT2A::AFF3 fusion resulting from a three-way chromosomal rearrangement in pediatric B lymphoblastic leukemia.

(Miller LJ, Leventaki V, Harker-Murray PD, Drendel HM, Bone KM.) Cancer Genet. 2022 Apr;262-263:43-46 PMID: 34995897 SCOPUS ID: 2-s2.0-85122276846 01/08/2022
Patient-Derived Ovarian Cancer Spheroids Rely on PI3K-AKT Signaling Addiction for Cancer Stemness and Chemoresistance.

(Parashar D, Geethadevi A, Mittal S, McAlarnen LA, George J, Kadamberi IP, Gupta P, Uyar DS, Hopp EE, Drendel H, Bishop EA, Bradley WH, Bone KM, Rader JS, Pradeep S, Chaluvally-Raghavan P.) Cancers (Basel). 2022 Feb 15;14(4) PMID: 35205706 PMCID: PMC8870411 02/26/2022