Nathan A. Ledeboer, PhD

Professor; Medical Director, Clinical Microbiology; Medical Director, Molecular Diagnostics

Locations

Pathology & Laboratory Medicine

Contact Information

Biography

Dr. Ledeboer’s primary responsibility is for the medical and technical oversight of the Clinical Microbiology and Molecular Diagnostics Laboratories. In this role he oversees development and implementation of new assays, oversees and sign out all testing performed in these laboratories, and consults with physician colleagues regarding test results and selection.

Specialties:

Clinical Microbiology
Molecular Pathology

Research Interests

Development of rapid molecular techniques for detection of infectious diseases

Host Response to Infection

Combining Digital Imaging and Artificial Intelligence

Molecular detection and epidemiology of Respiratory Viruses

Antimicrobial resistance

Plasma Microbial Cell-Free DNA Sequencing from over 15,000 Patients Identified a Broad Spectrum of Pathogens.

(Park SY, Chang EJ, Ledeboer N, Messacar K, Lindner MS, Venkatasubrahmanyam S, Wilber JC, Vaughn ML, Bercovici S, Perkins BA, Nolte FS.) J Clin Microbiol. 2023 Aug 23;61(8):e0185522 PMID: 37439686 PMCID: PMC10446866 SCOPUS ID: 2-s2.0-85168782097 07/13/2023
Costs and Consequences of a Novel Emergency Department Sepsis Diagnostic Test: The IntelliSep Index.

(Hollenbeak CS, Henning DJ, Geeting GK, Ledeboer NA, Faruqi IA, Pierce CG, Thomas CB, O'Neal HR Jr.) Crit Care Explor. 2023 Jul;5(7):e0942 PMID: 37465702 PMCID: PMC10351935 07/19/2023
Rapid identification of sepsis in the emergency department.

(Kraus CK, Nguyen HB, Jacobsen RC, Ledeboer NA, May LS, O'Neal HR Jr, Puskarich MA, Rice TW, Self WH, Rothman RE.) J Am Coll Emerg Physicians Open. 2023 Jun;4(3):e12984 PMID: 37284425 PMCID: PMC10239543 06/07/2023
A phase 2 trial of a topical antiseptic bundle in head and neck cancer surgery: Effects on surgical site infection and the oral microbiome.

(Zenga J, Atkinson S, Yen T, Massey B, Stadler M, Bruening J, Peppard W, Reuben M, Hayward M, Mesich B, Buchan B, Ledeboer N, Sanchez JL, Fraser R, Lin CW, Holtz ML, Awan M, Wong SJ, Puram SV, Salzman N.) EBioMedicine. 2022 Jul;81:104099 PMID: 35671624 PMCID: PMC9168040 SCOPUS ID: 2-s2.0-85131428877 06/08/2022
Cytotoxic CD8-positive T-lymphocyte infiltration in the lungs as a histological pattern of SARS-CoV-2 pneumonitis.

(Puzyrenko A, Felix JC, Ledeboer NA, Sun Y, Rui H, Sheinin Y.) Pathology. 2022 Jun;54(4):404-408 PMID: 34836647 PMCID: PMC8572726 SCOPUS ID: 2-s2.0-85119915379 11/28/2021
Erratum for Pancholi et al., Multicenter Evaluation of the Simplexa VZV Direct Assay for Detection of Varicella-Zoster Virus in Cerebrospinal Fluid and Lesion-Swab Specimens.

(Pancholi P, Relich RF, Chandrasekaran S, Dunn JJ, Granato PA, Harrington AT, Hansen GT, Ledeboer NA, Li Q, Sims MD, Uphoff TS, Greene W, Young S, Dhiman N.) J Clin Microbiol. 2022 May 18;60(5):e0052722 PMID: 35465725 PMCID: PMC9116167 SCOPUS ID: 2-s2.0-85130765793 04/26/2022
Comparison of Methods for Determining the Antibiotic Susceptibility of Aerococcus Species in a Clinical Setting.

(Scholtz SL, Faron ML, Buchan BW, Ledeboer NA.) Am J Clin Pathol. 2022 May 04;157(5):781-788 PMID: 34893797 SCOPUS ID: 2-s2.0-85129998230 12/12/2021
Multicenter Evaluation of the Simplexa VZV Direct Assay for Detection of Varicella-Zoster Virus in Cerebrospinal Fluid and Lesion-Swab Specimens.

(Pancholi P, Relich RF, Chandrasekaran S, Dunn JJ, Granato PA, Harrington AT, Hansen GT, Ledeboer NA, Li Q, Sims MD, Uphoff TS, Greene W, Young S, Dhiman N.) J Clin Microbiol. 2022 Apr 20;60(4):e0235521 PMID: 35285727 PMCID: PMC9020333 SCOPUS ID: 2-s2.0-85128801876 03/15/2022
Efficacy of a third SARS-CoV-2 mRNA vaccine dose among hematopoietic cell transplantation, CAR T cell, and BiTE recipients.

(Abid MB, Rubin M, Ledeboer N, Szabo A, Longo W, Mohan M, Shah NN, Fenske TS, Abedin S, Runaas L, D'Souza A, Chhabra S, Dhakal B, Hamadani M.) Cancer Cell. 2022 Apr 11;40(4):340-342 PMID: 35202585 PMCID: PMC8864440 SCOPUS ID: 2-s2.0-85127542763 02/25/2022
Rapid identification from rectal swabs of the clinically most relevant carbapenemase genes from gram-negative bacteria using the BD MAX Check-Points CPO Assay.

(García-Fernández S, Simner PJ, Thomson G, Faron M, Bosboom R, van Griethuijsen A, García-Castillo M, Harris R, Ledeboer NA, Cantón R, Thomson KS.) Diagn Microbiol Infect Dis. 2022 Jan;102(1):115554 PMID: 34678712 SCOPUS ID: 2-s2.0-85117421272 10/23/2021
SARS-CoV-2 Cycle Thresholds, Poverty, Race, and Clinical Outcomes.

(Rivera F, Gmehlin CG, Pezzin LE, Hanson R, Perez A, Singh S, Ledeboer NA, Buchan BW, Nattinger AB, Munoz-Price LS.) WMJ. 2021 Dec;120(4):301-304 PMID: 35025178 SCOPUS ID: 2-s2.0-85123460891 01/14/2022
Point-of-care COVID-19 testing in the emergency department: current status and future prospects.

(May L, Tran N, Ledeboer NA.) Expert Rev Mol Diagn. 2021 Dec;21(12):1333-1340 PMID: 34758686 PMCID: PMC8631689 SCOPUS ID: 2-s2.0-85120077883 11/12/2021