Wei Liu, PhD

Publications

• Structural Insights into Dopamine Receptor-Ligand Interactions: From Agonists to Antagonists.

  (Barbosa ED, Ma Y, Clift HE, Olson LJ, Zhu L, Liu W.) ACS Chem Neurosci. 2024 Nov 20;15(22):4123-4131 PMID: 39485723 SCOPUS ID: 2-s2.0-85208389275 11/01/2024

• CXXC5 drove inflammation and ovarian cancer proliferation via transcriptional activation of ZNF143 and EGR1.

  (Geng T, Sun Q, He J, Chen Y, Cheng W, Shen J, Liu B, Zhang M, Wang S, Asan K, Song M, Gao Q, Song Y, Liu R, Liu X, Ding Y, Jing A, Ye X, Ren H, Zeng K, Zhou Y, Zhang B, Ma S, Liu W, Liu S, Ji J.) Cell Signal. 2024 Jul;119:111180 PMID: 38642782 SCOPUS ID: 2-s2.0-85190884720 04/21/2024

• FOXP4-mediated induction of PTK7 activates the Wnt/β-catenin pathway and promotes ovarian cancer development.

  (Ji J, Qian Q, Cheng W, Ye X, Jing A, Ma S, Ding Y, Ma X, Wang Y, Sun Q, Wang X, Chen Y, Zhu L, Yuan Q, Xu M, Qin J, Ma L, Yang J, Zhang M, Geng T, Wang S, Wang D, Song Y, Zhang B, Xu Y, Xu L, Liu S, Liu W, Liu B.) Cell Death Dis. 2024 May 13;15(5):332 PMID: 38740744 PMCID: PMC11091054 SCOPUS ID: 2-s2.0-85192951272 05/14/2024

• FBXO5-mediated RNF183 degradation prevents endoplasmic reticulum stress-induced apoptosis and promotes colon cancer progression.

  (Ji J, Jing A, Ding Y, Ma X, Qian Q, Geng T, Cheng W, Zhang M, Sun Q, Ma S, Wang X, Yuan Q, Xu M, Qin J, Ma L, Yang J, He J, Du Q, Xia M, Xu Y, Chen Z, Zhu L, Liu W, Liu S, Liu B.) Cell Death Dis. 2024 Jan 11;15(1):33 PMID: 38212299 PMCID: PMC10784456 SCOPUS ID: 2-s2.0-85182091692 01/12/2024

• Structure-Based Lead Optimization of Enterovirus D68 2A Protease Inhibitors.

  (Tan B, Liu C, Li K, Jadhav P, Lambrinidis G, Zhu L, Olson L, Tan H, Wen Y, Kolocouris A, Liu W, Wang J.) J Med Chem. 2023 Nov 09;66(21):14544-14563 PMID: 37857371 PMCID: PMC11457037 SCOPUS ID: 2-s2.0-85176509223 10/20/2023

• Editorial: Protein modifications in epigenetic dysfunctional diseases: mechanisms and potential therapeutic strategies.

  (Ji J, Jing A, Geng T, Ma X, Liu W, Liu B.) Front Cell Dev Biol. 2023;11:1216637 PMID: 37255602 PMCID: PMC10225621 SCOPUS ID: 2-s2.0-85161055462 05/31/2023

• Cryo-EM structure of the human adenosine A2B receptor-Gs signaling complex.

  (Chen Y, Zhang J, Weng Y, Xu Y, Lu W, Liu W, Liu M, Hua T, Song G.) Sci Adv. 2022 Dec 23;8(51):eadd3709 PMID: 36563137 PMCID: PMC9788782 12/24/2022

• An Isochroman Analog of CD3254 and Allyl-, Isochroman-Analogs of NEt-TMN Prove to Be More Potent Retinoid-X-Receptor (RXR) Selective Agonists Than Bexarotene.

  (Jurutka PW, di Martino O, Reshi S, Mallick S, Sausedo MA, Moen GA, Lee IJ, Ivan DJ, Krall TD, Peoples SJ, Perez A, Tromba L, Le A, Khadka I, Petros R, Savage BM, Salama E, Salama J, Ziller JW, Noh Y, Lee MY, Liu W, Welch JS, Marshall PA, Wagner CE.) Int J Mol Sci. 2022 Dec 19;23(24) PMID: 36555852 PMCID: PMC9782500 12/24/2022

• Structural basis for receptor selectivity and inverse agonism in S1P5 receptors.

  (Lyapina E, Marin E, Gusach A, Orekhov P, Gerasimov A, Luginina A, Vakhrameev D, Ergasheva M, Kovaleva M, Khusainov G, Khorn P, Shevtsov M, Kovalev K, Bukhdruker S, Okhrimenko I, Popov P, Hu H, Weierstall U, Liu W, Cho Y, Gushchin I, Rogachev A, Bourenkov G, Park S, Park G, Hyun HJ, Park J, Gordeliy V, Borshchevskiy V, Mishin A, Cherezov V.) Nat Commun. 2022 Aug 12;13(1):4736 PMID: 35961984 PMCID: PMC9374744 SCOPUS ID: 2-s2.0-85135832975 08/13/2022

• Structures of β1-adrenergic receptor in complex with Gs and ligands of different efficacies.

  (Su M, Paknejad N, Zhu L, Wang J, Do HN, Miao Y, Liu W, Hite RK, Huang XY.) Nat Commun. 2022 Jul 14;13(1):4095 PMID: 35835792 PMCID: PMC9283524 SCOPUS ID: 2-s2.0-85134147752 07/15/2022

• Differential activation mechanisms of lipid GPCRs by lysophosphatidic acid and sphingosine 1-phosphate.

  (Liu S, Paknejad N, Zhu L, Kihara Y, Ray M, Chun J, Liu W, Hite RK, Huang XY.) Nat Commun. 2022 Feb 08;13(1):731 PMID: 35136060 PMCID: PMC8826421 SCOPUS ID: 2-s2.0-85124279039 02/10/2022

• Modeling, Synthesis, and Biological Evaluation of Potential Retinoid-X-Receptor (RXR) Selective Agonists: Analogs of 4-[1-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahyro-2-naphthyl)ethynyl]benzoic Acid (Bexarotene) and 6-(Ethyl(4-isobutoxy-3-isopropylphenyl)amino)nicotinic Acid (NEt-4IB).

  (Jurutka PW, di Martino O, Reshi S, Mallick S, Sabir ZL, Staniszewski LJP, Warda A, Maiorella EL, Minasian A, Davidson J, Ibrahim SJ, Raban S, Haddad D, Khamisi M, Suban SL, Dawson BJ, Candia R, Ziller JW, Lee MY, Liu C, Liu W, Marshall PA, Welch JS, Wagner CE.) Int J Mol Sci. 2021 Nov 16;22(22) PMID: 34830251 PMCID: PMC8624485 SCOPUS ID: 2-s2.0-85119007925 11/28/2021