Medical College of Wisconsin Liu Laboratory

We are in an era of big data. The more we can utilize bioinformatic tools and omics data, the closer we are towards novel strategies for heart regeneration. The Liu lab integrates a variety of omics approaches including single-cell omics, RNA-seq, CLIP-seq, Cut & Run, etc., with CRISPR screening and bioinformatic analyses to address fundamental biological questions.

We are particularly interested in post-transcriptional regulation of gene expression by RNA-binding proteins including splicing factors, as well as epigenetic regulation by epigenetic factors. Both are critical gene regulatory mechanisms but understudies in the context of heart regeneration.