Heather Himburg, PhD

Associate Professor, Radiation Oncology

Locations

Radiation Oncology

Contact Information

hhimburg@mcw.edu

Education

PhD, Biomedical Engineering, Duke University, Durham, NC, 2005
MS, Biomedical Engineering, Ohio State University, Columbus, OH, 2001
BS Physics, Miami University, Oxford, OH, 1998

Visit the Himburg Laboratory website

Biography

Training

Postdoctoral Fellow, Medicine, Cellular Therapy, Duke University, Durham, NC

Research Interests

Mitigation of hematopoietic acute radiation toxicity, role of the bone marrow microenvironment in regulating normal and malignant hematopoiesis, cancer stem cell biology

In silico identification of public neo-antigens in head and neck Cancer for T cell receptor Engineering: Targeting PI3KCA and TP53 missense mutations.

(Zenga J, Himburg HA, Wong SJ, Kearl T, Hematti P, Jin VX, Memon AA, Mathison AJ, Awan MJ.) Oral Oncol. 2024 Sep;156:106947 PMID: 39009483 SCOPUS ID: 2-s2.0-85198374252 07/16/2024
Epidermal growth factor augments the self-renewal capacity of aged hematopoietic stem cells.

(Chang VY, He Y, Grohe S, Brady MR, Chan A, Kadam RS, Fang T, Pang A, Pohl K, Tran E, Li M, Kan J, Zhang Y, Lu JJ, Sasine JP, Himburg HA, Yue P, Chute JP.) iScience. 2024 Jul 19;27(7):110306 PMID: 39055915 PMCID: PMC11269946 07/26/2024
Type I interferon signaling promotes radioresistance in head and neck cancer.

(Zenga J, Awan MJ, Frei A, Massey B, Bruening J, Shukla M, Sharma GP, Shreenivas A, Wong SJ, Zimmermann MT, Mathison AJ, Himburg HA.) Transl Cancer Res. 2024 May 31;13(5):2535-2543 PMID: 38881922 PMCID: PMC11170510 06/17/2024
Tumor-specific T cells in head and neck cancer have rescuable functionality and can be identified through single-cell co-culture.

(Zenga J, Awan M, Frei A, Foeckler J, Kuehn R, Espinosa OV, Bruening J, Massey B, Wong S, Shreenivas A, Shukla M, Kasprzak J, Sun Y, Shaheduzzaman M, Chen F, Kearl T, Himburg HA.) Transl Oncol. 2024 Apr;42:101899 PMID: 38320395 PMCID: PMC10851216 SCOPUS ID: 2-s2.0-85184507548 02/07/2024
Inhibition of Ephrin B2 Reverse Signaling Abolishes Multiple Myeloma Pathogenesis.

(Sasine JP, Kozlova NY, Valicente L, Dukov J, Tran DH, Himburg HA, Kumar S, Khorsandi S, Chan A, Grohe S, Li M, Kan J, Sehl ME, Schiller GJ, Reinhardt B, Singh BK, Ho R, Yue P, Pasquale EB, Chute JP.) Cancer Res. 2024 Mar 15;84(6):919-934 PMID: 38231476 PMCID: PMC10940855 SCOPUS ID: 2-s2.0-85187955711 01/17/2024
2nd Window NIR Imaging of Radiation Injury Mitigation Provided by Reduced Notch-Dll4 Expression on Vasculature.

(Kondelaji MHR, Sharma GP, Jagtap J, Shafiee S, Hansen C, Gasperetti T, Frei A, Veley D, Narayanan J, Fish BL, Parchur AK, Ibrahim EH, Medhora M, Himburg HA, Joshi A.) Mol Imaging Biol. 2024 Feb;26(1):124-137 PMID: 37530966 PMCID: PMC11188939 SCOPUS ID: 2-s2.0-85166543488 08/02/2023
In silico identification of public neo-antigens in head and neck Cancer for T cell receptor Engineering: Targeting PI3KCA and TP53 missense mutations

(Zenga J, Himburg HA, Wong SJ, Kearl T, Hematti P, Jin VX, Memon AA, Mathison AJ, Awan MJ.) Oral Oncology. September 2024;156 SCOPUS ID: 2-s2.0-85198374252 09/01/2024
Differential Response in Quantitative MRI Parameters Detected in Head and Neck Cancer Patients Treated with Concurrent Immunotherapy during Hypo-Fractionated MR-gRT.

(Bonate R, Paulson ES, Frei A, Shukla ME, Tarima S, Wong S, Himburg HA, Zenga J, Awan MJ.) Int J Radiat Oncol Biol Phys. 2023 Oct 01;117(2S):S65 PMID: 37784546 10/03/2023
Differential Response to Radiation Fractionation in Head and Neck Cancer Patient-Derived Xenografts.

(Musaddiq A, Zenga J, Frei A, Shukla ME, Himburg HA.) Int J Radiat Oncol Biol Phys. 2023 Oct 01;117(2S):e253 PMID: 37784980 10/03/2023
Photoactivated HPPH-Liposomal therapy for the treatment of HPV-Negative head and neck cancer.

(Zenga J, Awan M, Hadi Razeghi Kondelaji M, Hansen C, Shafiee S, Frei A, Foeckler J, Kuehn R, Bruening J, Massey B, Wong S, Joshi A, Himburg HA.) Oral Oncol. 2023 Sep;144:106487 PMID: 37423200 PMCID: PMC10413333 SCOPUS ID: 2-s2.0-85164978149 07/10/2023
X-ray and MR Contrast Bearing Nanoparticles Enhance the Therapeutic Response of Image-Guided Radiation Therapy for Oral Cancer.

(Sharma G, Razeghi Kondelaji MH, Sharma GP, Hansen C, Parchur AK, Shafiee S, Jagtap JM, Fish B, Bergom C, Paulson E, Hall WA, Himburg HA, Joshi A.) Technol Cancer Res Treat. 2023;22:15330338231189593 PMID: 37469184 PMCID: PMC10363893 SCOPUS ID: 2-s2.0-85165292958 07/20/2023
Biological sex differences in renin angiotensin system enzymes ACE and ACE2 regulate normal tissue response to radiation injury.

(Sharma GP, Frei A, Fish B, Gasperetti T, Veley D, Szalewski N, Nissen A, Himburg HA.) Front Physiol. 2023;14:1191237 PMID: 37275232 PMCID: PMC10235526 06/05/2023