Aoy Tomita Mitchell, PhD

Publications

• Evaluating threshold for donor fraction cell-free DNA using clinically available assay for rejection in pediatric and adult heart transplantation.

  (Deshpande SR, Zangwill SD, Richmond ME, Kindel SJ, Schroder JN, Gaglianello N, Bichell DP, Wigger MA, Knecht KR, Thrush PT, Mahle WT, North PE, Simpson PM, Zhang L, Dasgupta M, Tomita-Mitchell A, Mitchell ME.) Pediatr Transplant. 2024 May;28(3):e14708 PMID: 38553812 PMCID: PMC10987078 SCOPUS ID: 2-s2.0-85189497658 03/30/2024

• Nuclear Cell-Free DNA Predicts Adverse Events After Pediatric Cardiothoracic Surgery.

  (Tanem JM, Scott JP, Hoffman GM, Niebler RA, Tomita-Mitchell A, Stamm KD, Liang HL, North PE, Bertrandt RA, Woods RK, Hraska V, Mitchell ME.) Ann Thorac Surg. 2023 Aug;116(2):349-356 PMID: 36332680 SCOPUS ID: 2-s2.0-85150823960 11/05/2022

• Altered contractility, Ca2+ transients, and cell morphology seen in a patient-specific iPSC-CM model of Ebstein's anomaly with left ventricular noncompaction.

  (Thareja SK, Anfinson M, Cavanaugh M, Kim MS, Lamberton P, Radandt J, Brown R, Liang HL, Stamm K, Afzal MZ, Strande J, Frommelt MA, Lough JW, Fitts RH, Mitchell ME, Tomita-Mitchell A.) Am J Physiol Heart Circ Physiol. 2023 Jul 01;325(1):H149-H162 PMID: 37204873 PMCID: PMC10312315 SCOPUS ID: 2-s2.0-85164047409 05/19/2023

• Validation of donor fraction cell-free DNA with biopsy-proven cardiac allograft rejection in children and adults.

  (Richmond ME, Deshpande SR, Zangwill SD, Bichell DP, Kindel SJ, Mahle WT, Schroder JN, Wigger MA, Knecht KR, Pahl E, Gaglianello NA, Goetsch MA, Simpson P, Dasgupta M, Zhang L, North PE, Tomita-Mitchell A, Mitchell ME.) J Thorac Cardiovasc Surg. 2023 Feb;165(2):460-468.e2 PMID: 35643770 PMCID: PMC9617812 SCOPUS ID: 2-s2.0-85130912386 06/02/2022

• 3D-bioprinting of patient-derived cardiac tissue models for studying congenital heart disease.

  (Wolfe JT, He W, Kim MS, Liang HL, Shradhanjali A, Jurkiewicz H, Freudinger BP, Greene AS, LaDisa JF Jr, Tayebi L, Mitchell ME, Tomita-Mitchell A, Tefft BJ.) Front Cardiovasc Med. 2023;10:1162731 PMID: 37293290 PMCID: PMC10247285 SCOPUS ID: 2-s2.0-85161445064 06/09/2023

• Elevated nuclear and mitochondrial cell-free deoxyribonucleic acid measurements are associated with death after infant cardiac surgery.

  (Scott JP, Tanem JM, Tomita-Mitchell A, Hoffman GM, Niebler RA, Liang HL, Simpson PM, Stamm KD, North PE, Mitchell ME.) J Thorac Cardiovasc Surg. 2022 Aug;164(2):367-375 PMID: 35144816 SCOPUS ID: 2-s2.0-85120861361 02/12/2022

• Relationship between donor fraction cell-free DNA and clinical rejection in heart transplantation.

  (Deshpande SR, Zangwill SD, Kindel SJ, Schroder JN, Bichell DP, Wigger MA, Richmond ME, Knecht KR, Pahl E, Gaglianello NA, Mahle WT, Stamm KD, Simpson PM, Dasgupta M, Zhang L, North PE, Tomita-Mitchell A, Mitchell ME.) Pediatr Transplant. 2022 Jun;26(4):e14264 PMID: 35258162 SCOPUS ID: 2-s2.0-85125904987 03/09/2022

• Significance of α-Myosin Heavy Chain (MYH6) Variants in Hypoplastic Left Heart Syndrome and Related Cardiovascular Diseases.

  (Anfinson M, Fitts RH, Lough JW, James JM, Simpson PM, Handler SS, Mitchell ME, Tomita-Mitchell A.) J Cardiovasc Dev Dis. 2022 May 03;9(5) PMID: 35621855 PMCID: PMC9147009 05/28/2022

• A Systematic Review of Ebstein's Anomaly with Left Ventricular Noncompaction.

  (Thareja SK, Frommelt MA, Lincoln J, Lough JW, Mitchell ME, Tomita-Mitchell A.) J Cardiovasc Dev Dis. 2022 Apr 13;9(4) PMID: 35448091 PMCID: PMC9031964 SCOPUS ID: 2-s2.0-85129039352 04/22/2022

• Increase in nuclear cell-free DNA is associated with major adverse events in adult and pediatric heart transplant recipients.

  (Zangwill SD, Deshpande SR, Simpson PM, Liang HL, Zhang L, Dasgupta M, Richmond ME, Kindel SJ, Bichell DP, Mahle WT, Wigger MA, Schroder JN, Knecht KR, Pahl E, Gaglianello NA, North PE, Tomita-Mitchell A, Mitchell ME.) Clin Transplant. 2022 Jan;36(1):e14509 PMID: 34649304 SCOPUS ID: 2-s2.0-85120575732 10/15/2021

• Correction: Integrative analysis of genomic variants reveals new associations of candidate haploinsufficient genes with congenital heart disease.

  (Audain E, Wilsdon A, Breckpot J, Izarzugaza JMG, Fitzgerald TW, Kahlert AK, Sifrim A, Wünnemann F, Perez-Riverol Y, Abdul-Khaliq H, Bak M, Bassett AS, Benson DW, Berger F, Daehnert I, Devriendt K, Dittrich S, Daubeney PE, Garg V, Hackmann K, Hoff K, Hofmann P, Dombrowsky G, Pickardt T, Bauer U, Keavney BD, Klaassen S, Kramer HH, Marshall CR, Milewicz DM, Lemaire S, Coselli JS, Mitchell ME, Tomita-Mitchell A, Prakash SK, Stamm K, Stewart AFR, Silversides CK, Siebert R, Stiller B, Rosenfeld JA, Vater I, Postma AV, Caliebe A, Brook JD, Andelfinger G, Hurles ME, Thienpont B, Larsen LA, Hitz MP.) PLoS Genet. 2021 Sep;17(9):e1009809 PMID: 34547032 PMCID: PMC8454942 SCOPUS ID: 2-s2.0-85116272362 09/22/2021

• Estimate of the contemporary live-birth prevalence of recurrent 22q11.2 deletions: a cross-sectional analysis from population-based newborn screening.

  (Blagojevic C, Heung T, Theriault M, Tomita-Mitchell A, Chakraborty P, Kernohan K, Bulman DE, Bassett AS.) CMAJ Open. 2021;9(3):E802-E809 PMID: 34404688 PMCID: PMC8373039 SCOPUS ID: 2-s2.0-85114430327 08/19/2021