Christian Kastrup, PhD

Publications

• Rap1A Modulates Store-Operated Calcium Entry in the Lung Endothelium: A Novel Mechanism Controlling NFAT-Mediated Vascular Inflammation and Permeability.

  (Kosuru R, Romito O, Sharma GP, Ferraresso F, Ghadrdoost Nakhchi B, Yang K, Mammoto T, Mammoto A, Kastrup CJ, Zhang DX, Goldspink PH, Trebak M, Chrzanowska M.) Arterioscler Thromb Vasc Biol. 2024 Nov;44(11):2271-2287 PMID: 39324266 PMCID: PMC11495542 SCOPUS ID: 2-s2.0-85206451357 09/26/2024

• Regulation of hepatic inclusions and fibrinogen biogenesis by SEL1L-HRD1 ERAD.

  (Song Z, Thepsuwan P, Hur WS, Torres M, Wu SA, Wei X, Tushi NJ, Wei J, Ferraresso F, Paton AW, Paton JC, Zheng Z, Zhang K, Fang D, Kastrup CJ, Jaiman S, Flick MJ, Sun S.) Nat Commun. 2024 Oct 26;15(1):9244 PMID: 39455574 PMCID: PMC11512042 SCOPUS ID: 2-s2.0-85207624408 10/26/2024

• Genetic engineering of megakaryocytes from blood progenitor cells using messenger RNA lipid nanoparticles.

  (Leung J, Primbetova A, Strong C, Hay BN, Hsu HH, Hagner A, Foster LJ, Devine D, Cullis PR, Zandstra PW, Kastrup CJ.) J Thromb Haemost. 2024 Sep 26 PMID: 39341369 09/29/2024

• Protein is expressed in all major organs after intravenous infusion of mRNA-lipid nanoparticles in swine.

  (Ferraresso F, Badior K, Seadler M, Zhang Y, Wietrzny A, Cau MF, Haugen A, Rodriguez GG, Dyer MR, Cullis PR, Jan E, Kastrup CJ.) Mol Ther Methods Clin Dev. 2024 Sep 12;32(3):101314 PMID: 39253356 PMCID: PMC11382111 09/10/2024

• Suppressing upregulation of fibrinogen after polytrauma mitigates thrombosis in mice.

  (Seadler MS, Ferraresso F, Bansal M, Haugen A, Hayssen WG, Flick MJ, de Moya M, Dyer MR, Kastrup CJ.) J Trauma Acute Care Surg. 2024 Sep 06 PMID: 39238094 SCOPUS ID: 2-s2.0-85203525705 09/06/2024

• Genetic Engineering of Transfusable Platelets with mRNA-Lipid Nanoparticles is Compatible with Blood Banking Practices.

  (Strong C, Leung J, Kang E, Badior KE, Robertson MK, Pereyra N, Rowe EM, Wietrzny A, Ma B, Noronha Z, Arnold D, Ciufolini MA, Devine DV, Jan E, Cullis PR, Kastrup CJ.) Blood. 2024 Aug 27 PMID: 39190426 08/27/2024

• RNA therapeutics to control fibrinolysis: review on applications in biology and medicine.

  (Ferraresso F, Leung J, Kastrup CJ.) J Thromb Haemost. 2024 Aug;22(8):2103-2114 PMID: 38663489 PMCID: PMC11269028 04/26/2024

• siRNA-mediated reduction of a circulating protein in swine using lipid nanoparticles.

  (Cau MF, Ferraresso F, Seadler M, Badior K, Zhang Y, Ketelboeter LM, Rodriguez GG, Chen T, Ferraresso M, Wietrzny A, Robertson M, Haugen A, Cullis PR, de Moya M, Dyer M, Kastrup CJ.) Mol Ther Methods Clin Dev. 2024 Jun 13;32(2):101258 PMID: 38779336 PMCID: PMC11109470 05/23/2024

• Lipid nanoparticles and siRNA targeting plasminogen provide lasting inhibition of fibrinolysis in mouse and dog models of hemophilia A.

  (Strilchuk AW, Hur WS, Batty P, Sang Y, Abrahams SR, Yong ASM, Leung J, Silva LM, Schroeder JA, Nesbitt K, de Laat B, Moutsopoulos NM, Bugge TH, Shi Q, Cullis PR, Merricks EP, Wolberg AS, Flick MJ, Lillicrap D, Nichols TC, Kastrup CJ.) Sci Transl Med. 2024 Feb 21;16(735):eadh0027 PMID: 38381848 PMCID: PMC11293256 SCOPUS ID: 2-s2.0-85185823776 02/21/2024

• Genetically engineered transfusable platelets using mRNA lipid nanoparticles.

  (Leung J, Strong C, Badior KE, Robertson M, Wu X, Meledeo MA, Kang E, Paul M, Sato Y, Harashima H, Cap AP, Devine DV, Jan E, Cullis PR, Kastrup CJ.) Sci Adv. 2023 Dec;9(48):eadi0508 PMID: 38039367 PMCID: PMC10691771 SCOPUS ID: 2-s2.0-85178329611 12/01/2023

• Ruggedized Self-Propelling Hemostatic Gauze Delivers Low Dose of Thrombin and Systemic Tranexamic Acid and Achieves High Survival in Swine With Junctional Hemorrhage.

  (Ali-Mohamad N, Cau MF, Wang X, Khavari A, Ringgold K, Naveed A, Sherwood C, Peng N, Zhang Gao H, Zhang Y, Semple H, Peng H, Tenn C, Baylis JR, Beckett A, White NJ, Kastrup CJ.) Mil Med. 2023 Nov 08;188(Suppl 6):280-287 PMID: 37948225 11/10/2023

• Self-propelling thrombin powder enables hemostasis with no observable recurrent bleeding or thrombosis over 3 days in a porcine model of upper GI bleeding.

  (Ali-Mohamad N, Cau MF, Zenova V, Baylis JR, Beckett A, McFadden A, Donnellan F, Kastrup CJ.) Gastrointest Endosc. 2023 Aug;98(2):245-248 PMID: 37061138 04/16/2023