Young-In Chi, PhD

Assistant Professor, Department of Surgery; Research Scientist, Linda T. and John A. Mellowes Center for Genomic Sciences and Precision Medicine

Research Areas of Interest

Binding Sites
Crystallography, X-Ray
Diabetes Mellitus, Type 2
DNA-Binding Proteins
Gene Expression Regulation
Hepatocyte Nuclear Factor 1-alpha
Hepatocyte Nuclear Factor 1-beta
Hepatocyte Nuclear Factor 4
Models, Molecular
Molecular Docking Simulation
Molecular Dynamics Simulation
Molecular Structure

Research Experience

Crystallization
Crystallography, X-Ray
DNA-Binding Proteins
Models, Molecular
Molecular Docking Simulation
Molecular Dynamics Simulation
Molecular Structure
Protein Binding
Protein Conformation
Protein Interaction Domains and Motifs
Protein Structure, Tertiary
RNA

Computational structural genomics and clinical evidence suggest BCKDK gain-of-function may cause a potentially asymptomatic maple syrup urine disease phenotype.

(Singh E, Chi YI, Kopesky J, Zimmerman M, Urrutia R, Basel D, Schwoerer JS.) JIMD Rep. 2024 May;65(3):144-155 PMID: 38736638 PMCID: PMC11078707 SCOPUS ID: 2-s2.0-85193389190 05/13/2024
Writers and readers of H3K9me2 form distinct protein networks during the cell cycle that include candidates for H3K9 mimicry.

(Pollin G, De Assuncao TM, Doria Jorge S, Chi YI, Charlesworth MC, Madden B, Iovanna J, Zimmermann MT, Urrutia R, Lomberk G.) Biosci Rep. 2023 Oct 31;43(10) PMID: 37782747 PMCID: PMC10611923 SCOPUS ID: 2-s2.0-85175273435 10/02/2023
Deep computational phenotyping of genomic variants impacting the SET domain of KMT2C reveal molecular mechanisms for their dysfunction.

(Jorge SD, Chi YI, Mazaba JL, Haque N, Wagenknecht J, Smith BC, Volkman BF, Mathison AJ, Lomberk G, Zimmermann MT, Urrutia R.) Front Genet. 2023;14:1291307 PMID: 38090150 PMCID: PMC10715303 SCOPUS ID: 2-s2.0-85179362461 12/13/2023
A multi-layered computational structural genomics approach enhances domain-specific interpretation of Kleefstra syndrome variants in EHMT1.

(Chi YI, Jorge SD, Jensen DR, Smith BC, Volkman BF, Mathison AJ, Lomberk G, Zimmermann MT, Urrutia R.) Comput Struct Biotechnol J. 2023;21:5249-5258 PMID: 37954151 PMCID: PMC10632586 11/13/2023
Defining the Mutational Landscape That Affects the Histone Demethylase KDM6A/UTX in Human Cancer.

(Chi YI, Stodola TJ, de Assuncao TM, Volkman B, Smith B, Mathison AJ, Lomberk G, Zimmermann MT, Urrutia R.) FASEB J. 2022 May;36 Suppl 1 PMID: 35555661 SCOPUS ID: 2-s2.0-85130046941 05/14/2022
Integrative Modeling, Molecular Mechanics, and Molecular Dynamics Evaluation of Genomics Variants in KMT2C (MLL3), a Gene Involved in Kleefstra Syndrome Type 2.

(Jorge SD, Chi YI, de Assuncao TM, Mathison AJ, Volkman B, Smith B, Lomberk G, Zimmermann MT, Urrutia R.) FASEB J. 2022 May;36 Suppl 1 PMID: 35553749 SCOPUS ID: 2-s2.0-85130006059 05/14/2022
Structural bioinformatics enhances the interpretation of somatic mutations in KDM6A found in human cancers.

(Chi YI, Stodola TJ, De Assuncao TM, Leverence EN, Smith BC, Volkman BF, Mathison AJ, Lomberk G, Zimmermann MT, Urrutia R.) Comput Struct Biotechnol J. 2022;20:2200-2211 PMID: 35615018 PMCID: PMC9111933 SCOPUS ID: 2-s2.0-85130080827 05/27/2022
Computational modeling reveals key molecular properties and dynamic behavior of disruptor of telomeric silencing 1-like (DOT1L) and partnering complexes involved in leukemogenesis.

(Stodola TJ, Chi YI, De Assuncao TM, Leverence EN, Tripathi S, Dsouza NR, Mathison AJ, Volkman BF, Smith BC, Lomberk G, Zimmermann MT, Urrutia R.) Proteins. 2022 Jan;90(1):282-298 PMID: 34414607 PMCID: PMC8671179 SCOPUS ID: 2-s2.0-85114677469 08/21/2021
Correction to: Molecular mechanics and dynamic simulations of well-known Kabuki syndrome-associated KDM6A variants reveal putative mechanisms of dysfunction.

(Chi YI, Stodola TJ, De Assuncao TM, Leverence EN, Tripathi S, Dsouza NR, Mathison AJ, Basel DG, Volkman BF, Smith BC, Lomberk G, Zimmermann MT, Urrutia R.) Orphanet J Rare Dis. 2021 Jun 01;16(1):247 PMID: 34074320 PMCID: PMC8170813 SCOPUS ID: 2-s2.0-85107273180 06/03/2021
Molecular mechanics and dynamic simulations of well-known Kabuki syndrome-associated KDM6A variants reveal putative mechanisms of dysfunction.

(Chi YI, Stodola TJ, De Assuncao TM, Leverence EN, Tripathi S, Dsouza NR, Mathison AJ, Basel DG, Volkman BF, Smith BC, Lomberk G, Zimmermann MT, Urrutia R.) Orphanet J Rare Dis. 2021 Feb 05;16(1):66 PMID: 33546721 PMCID: PMC7866879 SCOPUS ID: 2-s2.0-85100579633 02/07/2021
Protein lysine 43 methylation by EZH1 promotes AML1-ETO transcriptional repression in leukemia.

(Dou L, Yan F, Pang J, Zheng D, Li D, Gao L, Wang L, Xu Y, Shi J, Wang Q, Zhou L, Shen N, Singh P, Wang L, Li Y, Gao Y, Liu T, Chen C, Al-Kali A, Litzow MR, Chi YI, Bode AM, Liu C, Huang H, Liu D, Marcucci G, Liu S, Yu L.) Nat Commun. 2019 Nov 07;10(1):5051 PMID: 31699991 PMCID: PMC6838331 SCOPUS ID: 2-s2.0-85074693036 11/09/2019
ErbB3-binding protein 1 (EBP1) represses HNF4α-mediated transcription and insulin secretion in pancreatic β-cells.

(Han EH, Singh P, Lee IK, Urrutia R, Chi YI.) J Biol Chem. 2019 Sep 20;294(38):13983-13994 PMID: 31362984 PMCID: PMC6755798 SCOPUS ID: 2-s2.0-85072530867 08/01/2019

Young-In Chi, PhD

Assistant Professor, Department of Surgery; Research Scientist, Linda T. and John A. Mellowes Center for Genomic Sciences and Precision Medicine

Research Areas of Interest

Research Experience

Publications