Hayley Powers, PhD

Cholesterol clearance, structural biology, cardiovascular disease, endocrinology, cardiology

Research Experience

Medical College of Wisconsin, 2018-2023
Advisor: Daisy Sahoo, PhD
Project: Identification of structural features of SR-BI that facilitate HDL-cholesterol clearance (F30HL151048)

University of Wisconsin-La Crosse, 2014-2016
Advisor: Margaret Maher
Project: AGEs, nutrient uptake, and the use of enzymatic supplements

Medical College of Wisconsin, 2015
Advisor: Allison Ebert
Project: Derivation of serotonergic neurons from induced pluripotent stem cells (iPSCs)

Publications

Dai W, Zhang H, Lund H, Zhang Z, Castleberry M, Rodriguez M, Kuriakose G, Gupta S, Lewandowska M, Powers HR, Valmiki S, Zhu J, Shapiro AD, Hussain MM, López JA, Sorci-Thomas MG, Silverstein RL, Ginsberg HN, Sahoo D, Tabas I, Zheng Z. Intracellular tPA-PAI-1 interaction determines VLDL assembly in hepatocytes. Science. 2023 Sep;381(6661):eadh5207. doi: 10.1126/science.adh5207. Epub 2023 Sep 1. PMID: 37651538.

Powers HR, Jenjak SE, Volkman BF, Sahoo D. Development and validation of a purification system for functional full-length human SR-B1 and CD36. J Biol Chem. 2023 Aug 23;299(10):105187. doi: 10.1016/j.jbc.2023.105187. Epub ahead of print. PMID: 37625590; PMCID: PMC10509710.

Powers HR, Sahoo D. SR-B1's Next Top Model: Structural Perspectives on the Functions of the HDL Receptor. Curr Atheroscler Rep. 2022 Apr;24(4):277-288. PMID: 35107765.

Schill RL, Knaack DA, Powers HR, Chen Y, Yang M, Schill DJ, Silverstein RL, Sahoo D. Modification of HDL by Reactive Aldehydes Alters Select Cardioprotective Functions of HDL in Macrophages. FEBS J. 2020 Feb;287(4):695-707. PMID: 31386799.

Meeting Abstracts

Powers HR & Sahoo D. Novel Human Variants of SR-B1 Impact HDL-Cholesterol Clearance. HDL Workshop, Boston, MA. 2023. [Oral]

Powers HR & Sahoo D. Novel Human Variants of SR-B1 Impact HDL-Cholesterol Clearance. Vascular Discovery, Boston, MA. May 2023. [Poster]

Powers HR, Jenjak SE, Volkman BF, Sahoo D. A Tale of Two Scavenger Receptors: Structure-Function Relationships of Purified SR-B1 and CD36. Lipoprotein Metabolism Gordon Research Symposium, Southbridge, MA. May 2022. [Oral]

Powers HR, Jenjak SE, Volkman BF, Sahoo D. Selected abstract of excellence. Into the Wormhole: Understanding SR-B1's Cholesterol Transport Functions Through Structural Studies. Vascular Discovery, Seattle, WA. May 2022. https://doi.org/10.1161/atvb.42.suppl_1.119. [Oral]

Powers HR, Jenjak SE, Volkman BF, Sahoo D. Into the Wormhole: Understanding SR-B1's Cholesterol Transport Functions Through Structural Studies. Vascular Discovery, Seattle, WA, May 2022. https://doi.org/10.1161/atvb.42.suppl_1.206. [Poster]

Powers HR, Jenjak SE, Volkman BF, Sahoo D A Tale of Two Scavenger Receptors: Structure-Function Relationships of Purified SR-B1 and CD36. American Society for Biochemistry and Molecular Biology (ASBMB)/Experimental Biology, Philadelphia, PA, April 2022. https://doi.org/10.1096/fasebj.2022.36.S1.R5661 [Poster]

Powers HR, Jenjak SE, Volkman BF, Sahoo D. Building a Structurally Sound System to Understand SR-BI Function. Vascular Discovery, Virtual Conference, September 2021. https://doi.org/10.1161/atvb.41.suppl_1.P115. [Virtual Poster]

Powers HR, Jenjak SE, Volkman BF, Sahoo D. Bugging Out Over SR-BI's Structure Function Relationships. 36th Annual MD/PhD Student Conference, Virtual, July 2021. [Virtual Poster]

Powers HR, Jenjak SE, Volkman BF, Sahoo D. Developing a Purification System to Assess SR-BI Structure and Function.American Society for Biochemistry and Molecular Biology (ASBMB)/Experimental Biology, Virtual, April 2021. https://doi.org/10.1096/fasebj.2021.35.S1.02333. [Virtual Poster]

Powers HR, Proudfoot SC, Feix JB, Sahoo D. (2020, May 5-7). Utilizing Nanodiscs to Model Membrane Interactions with SR-BI . Vascular Discovery, Chicago, IL. [Virtual Poster]

Powers HR, Proudfoot SC, Feix JB, Sahoo D. (2020, March 6). Utilizing Nanodiscs to Model Membrane Interactions with SR-BI . Department of Medicine Research Retreat, Milwaukee, WI. [Poster]

Powers HR, Proudfoot SC, Feix JB, Sahoo D. (2019, October 18). Utilizing Nanodiscs to Model Membrane Interactions with SR-BI. Cardiovascular Center Research Retreat, Milwaukee, WI. [Poster]

Powers HR. Selected abstract of excellence. Utilizing Nanodiscs to Model Membrane Interactions with SR-BI. Vascular Discovery, Virtual, Mat 2020. https://doi.org/10.1161/atvb.41.suppl_1.P115. [Oral]

Powers HR, Breunig A, Verissimo F, Silvamen T, Oliveira A, De Oliveira M, De Araujo Lima S, Maher, M. Serum Advanced Glycation End Products (AGE) of Humans before and after Consumption of an AGE-Rich Meal. Experimental Biology, San Diego, CA April 2016. https://faseb.onlinelibrary.wiley.com/doi/abs/10.1096/fasebj.30.1_supplement.907.16. [Poster]

General Interests

Social justice, traveling, tennis, concerts, collecting vinyl, and weightlifting