![Karina Bursch](/-/media/MCW/Education/Medical-Scientist-Training-Program/Students/Karina-Bursch_Academic-Profile.jpg?scale=both&w=1089&anchor=middlecenter&mode=crop&h=1225&la=en&hash=8FF812354431A0CF1B50D6D132B7431D)
Karina Bursch
G4 Student
Faculty Advisor
- Brian Smith, PhD, Biochemistry
Locations
- Medical Scientist Training Program
Contact Information
Education
Research Interests
Cancer Biology, Immunology, Biochemistry
Research Experience
Medical College of Wisconsin, 2021-present
Advisor: Brian Smith, PhD
Project: PBRM1 bromodomain missense mutations in ccRCC vascular signaling (F30CA278386)
The Catholic University of America, January 2017- May 2019
Advisor: Byung Min (Justin) Chung, PhD
Project: Elucidating the role of Keratin 19 (K19) in the proliferation and migration of MCF7 breast cancer cells.
MD Anderson Cancer Center, June 2018-August 2018
Advisor: Powel Brown, MD, PhD
Project: Determining the effect of the rexinoid IRX 4204 on the proliferation of a panel of breast cancer cell lines.
University of Minnesota, June 2017-August 2017
Advisor: Gregory Vercellotti, MD, FACP
Project: Characterizing the heme binding site on the MD-2/TLR4 transmembrane protein complex.
Publications
Shishodia S, Nuñez R, Strohmier BP, Bursch KL, Goetz CJ, Olp MD, Jensen DR, Fenske TG, Ordonez-Rubiano SC, Blau ME, Roach MK, Peterson FC, Volkman BF, Dykhuizen EC, Smith BC. Selective and Cell-Active PBRM1 Bromodomain Inhibitors Discovered through NMR Fragment Screening. J Med Chem. 2022 Oct 27;65(20):13714-13735. doi: 10.1021/acs.jmedchem.2c00864. Epub 2022 Oct 13. PMID: 36227159; PMCID: PMC9630929.
Khan M, Roddy JT, Hernandez JR, Bursch K, Bal N, Carlson KS, Bergl PA. Revisiting biochemistry: severe euglycemic ketoacidosis in the setting of IDH-inhibitor therapy for AML. Br J Haematol. 2021 Sep;194(6):1083-1085. doi: 10.1111/bjh.17576. Epub 2021 Jun 7. PMID: 34101165.
Alsharif S, Sharma P, Bursch K, Milliken R, Lam V, Fallatah A, Phan T, Collins M, Dohlman P, Tiufekchiev S, Nehmetallah G, Raub CB, Chung BM. Keratin 19 maintains E-cadherin localization at the cell surface and stabilizes cell-cell adhesion of MCF7 cells. Cell Adh Migr. 2021 Dec;15(1):1-17. doi: 10.1080/19336918.2020.1868694. PMID: 33393839; PMCID: PMC7801129.
Sharma P, Alsharif S, Bursch K, Parvathaneni S, Anastasakis DG, Chahine J, Fallatah A, Nicolas K, Sharma S, Hafner M, Kallakury B, Chung BM. Keratin 19 regulates cell cycle pathway and sensitivity of breast cancer cells to CDK inhibitors. Sci Rep. 2019 Oct 10;9(1):14650. doi: 10.1038/s41598-019-51195-9. PMID: 31601969; PMCID: PMC6787034.
Meeting Abstracts
Bursch K, Goetz C, Nuñez R, Jiao G, Olp M, Jorge S, Urrutia R, Dykhuizen E, Smith B. Cancer-associated missense mutations in the tumor suppressor Polybromo-1 variably affect protein stability and function. Abstract for a poster presentation at the annual American Society for Biochemistry and Molecular Biology (ASBMB) conference, Seattle, WA (March 2023))
Bursch KL and Smith BC. Cancer-associated missense mutations in the tumor suppressor Polybromo-1 variably affect protein stability and function. Abstract for oral and poster presentation at the 2023 MCW Cancer Center Scientific Retreat, Milwaukee, WI (May 2023)
General Interests
Playing cello and piano, traveling, running, and baking