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MSTP students in the Sahoo lab

Medical Scientist Training Program

Siying Lin

G4 Student

Faculty Advisor

Weiguo Cui, PhD, Microbiology & Immunology

Locations

Medical Scientist Training Program

Contact Information

silin@mcw.edu

Education

BS, Biochemistry, The Catholic University of America, 2016

Research Interests

Immunology; infectious diseases

Research Experience

Medical College of Wisconsin, 2021-present
Advisor: Weiguo Cui, PhD
Project: Differentiating the genomic profiles of CART responders vs. non-responders

NIH/NIAID/LIR/HSIS, 2016-2019
Advisors: Drs. Mark Connors and Stephen Migueles
Projects: 1) Investigating the mechanisms of CD8+ T-cell mediated control of HIV replication in Long term non-progressors/ Elite controllers (LTNPs/ECs). 2) Investigating the mechanisms of low HIV-specific CD8+ T-cell cytotoxicity in Ad5/HIV Vaccines.

The Catholic University of America/ Biology Department, 2014-2017
Advisor: Dr. Venigalla B. Rao
Project: Investigating the mechanism of how the rate of the DNA packaging motor protein is regulated in bacteriophage T4.

Publications

Shen J, Lin S, Cui W. Releasing the TLE3 break to put TCM cells on a fast track. Nat Immunol. 2024 Feb;25(2):191-193. doi: 10.1038/s41590-023-01732-6. PMID: 38238607.

Topchyan P, Lin S, Cui W. The Role of CD4 T Cell Help in CD8 T Cell Differentiation and Function During Chronic Infection and Cancer. Immune Netw. 2023 Oct 23;23(5):e41. doi: 10.4110/in.2023.23.e41. PMID: 37970230; PMCID: PMC10643329.

Topchyan P, Zander R, Kasmani MY, Nguyen C, Brown A, Lin S, Burns R, Cui W. Spatial transcriptomics demonstrates the role of CD4 T cells in effector CD8 T cell differentiation during chronic viral infection. Cell Rep. 2022 Nov 29;41(9):111736. doi: 10.1016/j.celrep.2022.111736. PMID: 36450262; PMCID: PMC9792173.

Zhang N, Lin S, Cui W, Newman PJ. Overlapping and unique substrate specificities of ST3GAL1 and 2 during hematopoietic and megakaryocytic differentiation. Blood Adv. 2022 Jul 12;6(13):3945-3955. doi: 10.1182/bloodadvances.2022007001. PMID: 35507766; PMCID: PMC9278294.

General Interests

Biking, hiking, skiing, backcountry backpacking, and watching The Office