Mahfoud Assem, PharmD, PhD

Publications

• Microarray Determination of the Expression of Drug Transporters in Humans and Animal Species Used for the Investigation of Nasal Absorption.

  (Al-Ghabeish M, Scheetz T, Assem M, Donovan MD.) Mol Pharm. 2015 Aug 03;12(8):2742-54 PMID: 26106909 PMCID: PMC4671632 06/25/2015

• Gene expression and immunochemical localization of major cytochrome P450 drug-metabolizing enzymes in bovine nasal olfactory and respiratory mucosa.

  (Dhamankar V, Assem M, Donovan MD.) Inhal Toxicol. 2015;27(14):767-77 PMID: 26572092 PMCID: PMC4970319 11/18/2015

• NOTCH3 is a prognostic factor that promotes glioma cell proliferation, migration and invasion via activation of CCND1 and EGFR.

  (Alqudah MA, Agarwal S, Al-Keilani MS, Sibenaller ZA, Ryken TC, Assem M.) PLoS One. 2013;8(10):e77299 PMID: 24143218 PMCID: PMC3797092 10/22/2013

• Tumor derived mutations of protein tyrosine phosphatase receptor type k affect its function and alter sensitivity to chemotherapeutics in glioma.

  (Agarwal S, Al-Keilani MS, Alqudah MA, Sibenaller ZA, Ryken TC, Assem M.) PLoS One. 2013;8(5):e62852 PMID: 23696788 PMCID: PMC3656086 05/23/2013

• Enhancing diagnosis, prognosis, and therapeutic outcome prediction of gliomas using genomics.

  (Assem M, Sibenaller Z, Agarwal S, Al-Keilani MS, Alqudah MA, Ryken TC.) OMICS. 2012 Mar;16(3):113-22 PMID: 22401657 PMCID: PMC3300066 03/10/2012

• Constitutive androstane receptor activation decreases plasma apolipoprotein B-containing lipoproteins and atherosclerosis in low-density lipoprotein receptor-deficient mice.

  (Sberna AL, Assem M, Xiao R, Ayers S, Gautier T, Guiu B, Deckert V, Chevriaux A, Grober J, Le Guern N, Pais de Barros JP, Moore DD, Lagrost L, Masson D.) Arterioscler Thromb Vasc Biol. 2011 Oct;31(10):2232-9 PMID: 21778422 PMCID: PMC4104927 07/23/2011

• Constitutive androstane receptor activation stimulates faecal bile acid excretion and reverse cholesterol transport in mice.

  (Sberna AL, Assem M, Gautier T, Grober J, Guiu B, Jeannin A, Pais de Barros JP, Athias A, Lagrost L, Masson D.) J Hepatol. 2011 Jul;55(1):154-61 PMID: 21145854 12/15/2010

• The major human pregnane X receptor (PXR) splice variant, PXR.2, exhibits significantly diminished ligand-activated transcriptional regulation.

  (Lin YS, Yasuda K, Assem M, Cline C, Barber J, Li CW, Kholodovych V, Ai N, Chen JD, Welsh WJ, Ekins S, Schuetz EG.) Drug Metab Dispos. 2009 Jun;37(6):1295-304 PMID: 19251824 PMCID: PMC2683691 03/03/2009

• The SWI/SNF chromatin-remodeling complex and glucocorticoid resistance in acute lymphoblastic leukemia.

  (Pottier N, Yang W, Assem M, Panetta JC, Pei D, Paugh SW, Cheng C, Den Boer ML, Relling MV, Pieters R, Evans WE, Cheok MH.) J Natl Cancer Inst. 2008 Dec 17;100(24):1792-803 PMID: 19066270 PMCID: PMC2639326 12/11/2008

• Activation of the constitutive androstane receptor decreases HDL in wild-type and human apoA-I transgenic mice.

  (Masson D, Qatanani M, Sberna AL, Xiao R, Pais de Barros JP, Grober J, Deckert V, Athias A, Gambert P, Lagrost L, Moore DD, Assem M.) J Lipid Res. 2008 Aug;49(8):1682-91 PMID: 18441373 04/29/2008

• Expression of SMARCB1 modulates steroid sensitivity in human lymphoblastoid cells: identification of a promoter SNP that alters PARP1 binding and SMARCB1 expression.

  (Pottier N, Cheok MH, Yang W, Assem M, Tracey L, Obenauer JC, Panetta JC, Relling MV, Evans WE.) Hum Mol Genet. 2007 Oct 01;16(19):2261-71 PMID: 17616514 07/10/2007

• A common polymorphism in the bile acid receptor farnesoid X receptor is associated with decreased hepatic target gene expression.

  (Marzolini C, Tirona RG, Gervasini G, Poonkuzhali B, Assem M, Lee W, Leake BF, Schuetz JD, Schuetz EG, Kim RB.) Mol Endocrinol. 2007 Aug;21(8):1769-80 PMID: 17519356 05/24/2007