Gopinath Tata, PhD

Assistant Professor

Locations

Biophysics
MFRC 2060

Contact Information

Education

Postdoctoral Fellow in Biochemistry, Molecular Biology and Biophysics (BMBB), University of Minnesota, 2007-2010
PhD, Indian Institute of Science, Bangalore, India, 2007
MSc, University of Hyderabad, India, 2001

Biography

I am an nuclear magnetic resonance (NMR) scientist with proven accomplishments. My research focuses on solution- and solid-state NMR spectroscopy, and structural analysis of small molecules and proteins.

Research Interests

My research interests are as follows:

Solution NMR
Solid-state NMR
Protein Biophysics
Membrane proteins
Lipids
Pharmaceutical drugs
Molecular dynamics simulations
NMR hardware
Pulse sequence developments
NMR of semi-solid tissue samples
Molecular dynamics simulations
AI (artificial intelligence) algorithms and applications to NMR
Quantum Computing and Quantum Information Processing

A pH-sensitive motif in an outer membrane protein activates bacterial membrane vesicle production.

(Dehinwal R, Gopinath T, Smith RD, Ernst RK, Schifferli DM, Waldor MK, Marassi FM.) Nat Commun. 2024 Aug 13;15(1):6958 PMID: 39138228 PMCID: PMC11322160 SCOPUS ID: 2-s2.0-85201246120 08/14/2024
Solid-state NMR MAS CryoProbe enables structural studies of human blood protein vitronectin bound to hydroxyapatite.

(Gopinath T, Shin K, Tian Y, Im W, Struppe J, Perrone B, Hassan A, Marassi FM.) J Struct Biol. 2024 Mar;216(1):108061 PMID: 38185342 PMCID: PMC10939839 SCOPUS ID: 2-s2.0-85182378487 01/08/2024
PHRONESIS: A One-Shot Approach for Sequential Assignment of Protein Resonances by Ultrafast MAS Solid-State NMR Spectroscopy.

(Gopinath T, Manu VS, Weber DK, Veglia G.) Chemphyschem. 2022 Jul 05;23(13):e202200127 PMID: 35499980 PMCID: PMC9400877 SCOPUS ID: 2-s2.0-85130396254 05/03/2022
A kink in DWORF helical structure controls the activation of the sarcoplasmic reticulum Ca2+-ATPase.

(Reddy UV, Weber DK, Wang S, Larsen EK, Gopinath T, De Simone A, Robia S, Veglia G.) Structure. 2022 Mar 03;30(3):360-370.e6 PMID: 34875216 PMCID: PMC8897251 SCOPUS ID: 2-s2.0-85123018206 12/08/2021
Structural basis for sarcolipin's regulation of muscle thermogenesis by the sarcoplasmic reticulum Ca2+-ATPase.

(Wang S, Gopinath T, Larsen EK, Weber DK, Walker C, Uddigiri VR, Mote KR, Sahoo SK, Periasamy M, Veglia G.) Sci Adv. 2021 Nov 26;7(48):eabi7154 PMID: 34826239 PMCID: PMC8626070 SCOPUS ID: 2-s2.0-85120338258 11/27/2021
Structural basis for allosteric control of the SERCA-Phospholamban membrane complex by Ca2+ and phosphorylation.

(Weber DK, Reddy UV, Wang S, Larsen EK, Gopinath T, Gustavsson MB, Cornea RL, Thomas DD, De Simone A, Veglia G.) Elife. 2021 May 12;10 PMID: 33978571 PMCID: PMC8184213 SCOPUS ID: 2-s2.0-85108020453 05/13/2021
Solid-State NMR of Membrane Proteins in Lipid Bilayers: To Spin or Not To Spin?

(Gopinath T, Weber D, Wang S, Larsen E, Veglia G.) Acc Chem Res. 2021 Mar 16;54(6):1430-1439 PMID: 33655754 PMCID: PMC11457538 SCOPUS ID: 2-s2.0-85102964601 03/04/2021
Simultaneous acquisition of multiple fast MAS solid-state NMR experiments via orphan spin polarization

(Gopinath T, Veglia G.) Annual Reports on NMR Spectroscopy. January 2021;102:247-268 SCOPUS ID: 2-s2.0-85099955760 01/01/2021
Molecular Mechanism for the Suppression of Alpha Synuclein Membrane Toxicity by an Unconventional Extracellular Chaperone.

(Ahmed R, Huang J, Weber DK, Gopinath T, Veglia G, Akimoto M, Khondker A, Rheinstädter MC, Huynh V, Wylie RG, Bozelli JC Jr, Epand RM, Melacini G.) J Am Chem Soc. 2020 May 27;142(21):9686-9699 PMID: 32383602 SCOPUS ID: 2-s2.0-85085657558 05/10/2020
Multi-receiver solid-state NMR using polarization optimized experiments (POE) at ultrafast magic angle spinning.

(Gopinath T, Weber DK, Veglia G.) J Biomol NMR. 2020 May;74(4-5):267-285 PMID: 32333193 PMCID: PMC7236978 SCOPUS ID: 2-s2.0-85083825531 04/26/2020
Hybridizing isotropic and anisotropic solid-state NMR restraints for membrane protein structure determination

(Weber DK, Larsen EK, Gopinath T, Veglia G.) Solid-State NMR: Applications in biomembrane structure. 3 December 2020:12.1-12.21 SCOPUS ID: 2-s2.0-85180138686 12/03/2020
Proton-detected polarization optimized experiments (POE) using ultrafast magic angle spinning solid-state NMR: Multi-acquisition of membrane protein spectra.

(Gopinath T, Veglia G.) J Magn Reson. 2020 Jan;310:106664 PMID: 31837552 PMCID: PMC7003683 SCOPUS ID: 2-s2.0-85076263034 12/15/2019