Medical College of Wisconsin Biophysics Job Openings

Position. The Medical College of Wisconsin (MCW) Cancer Center (CC) in partnership with basic science departments (Biochemistry, Biophysics, Pharmacology & Toxicology, Cell Biology, Neuroscience & Anatomy, Microbiology & Immunology) has made a strategic decision to expand on its strengths in Structural and Chemical Biology (SCB) and now invites applications for tenure-track positions at all levels.

This cluster recruitment seeks individuals to establish internationally leading research programs that apply the tools of structural biology to fundamental questions in cancer biology or cancer therapeutics. The ideal candidate will focus on cryo-EM (Single-particle Analysis (SPA) or in-situ cryo-ET) and SPA data science. MCW is equipped with a state-of-the-art 200-keV cryo-EM with direct electron detector and energy filter capable of final data collection for sub-4Å structure determination. MCW Cryo-EM researchers have expanded instrumentation opportunities through participation in a statewide Cryo-EM consortium that includes the University of Wisconsin-Madison’s Cryo-EM Research Center, which is within 60 miles from MCW and currently houses five new cryo-EMs, including two Titan Krios.

Qualifications. Applicants must have a doctoral degree in structural biology, biochemistry, biophysics or related discipline, at least two years of postdoctoral training, a strong publication record investigating structural and functional properties of biomolecules of cancer therapeutic relevance, and potential to obtain cancer-related extramural funding. MCW is intent on attracting, developing, and retaining a diverse workforce and faculty body that reflects the community we serve. We value diversity of backgrounds, experience, thought, and perspectives to advance excellence in science and medicine. MCW is a welcoming campus community with a strong culture of collaboration, partnership, and engagement with our surrounding community.

To apply. Please submit the following components to www.mcw.edu/careers (requisition #31368):

1. Cover letter
2. Curriculum vitae
3. Summary of research accomplishments (4-page maximum) and future research plans (4-page maximum)
4. Names and contact information of four references

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Position Description

Every day, in ways both big and small, the Medical College of Wisconsin (MCW) is impacting lives for the better. In the role of Postdoctoral Fellow you will be working in Biophysics.

Purpose
The Marassi laboratory in the Department of Biophysics at the Medical College of Wisconsin (MCW) invites applications for a postdoctoral position in the area of structural biology. Research projects focus on protein-protein, protein-lipid, and protein-biomineral interactions in the context of host-pathogen interactions and diseases of aging (macular degeneration and Alzheimer's disease), with a strong focus on cellular and near-native samples.

Candidates must have a PhD degree in chemistry, biochemistry, biophysics, or closely related field, and should have experience in biochemistry and/or biomolecular structure determination. The successful candidate will participate in experimental and computational structural biology studies, data analysis, and manuscript preparation to advance research goals.

State-of-the-art research resources are available for NMR in solution and the solid-state, EPR, X-ray crystallography, cryo-EM, mass spectrometry, biomolecular analysis, and high-performance computing.

For more information, see www.mcw.edu/Biophysics.

Primary Functions

• Independently design and perform experiments.
• Record and compile experimental results.
• Analyze experimental data.
• Prepare text and graphic results for manuscripts and presentations.
• Present at and participate in scientific meetings held the laboratory and at conferences.

Qualifications

• PhD degree in chemistry, biochemistry, biophysics, or closely related field.
• Experience in biochemistry and/or biomolecular structure determination.
• Understanding of general and complex laboratory procedures and scientific methods.
• Ability to work independently to develop and apply research protocols.

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Position Description
We’re looking for those individuals—the creative thinkers and innovation seekers—who are content with nothing short of changing the world. Discover the endless opportunities within the Medical College of Wisconsin (MCW) and be inspired by the work we can do together to improve health and make a positive, daily impact in our communities. In the role of a Postdoctoral Fellow you will be working in Biophysics.

Purpose
A postdoctoral fellowship position is open in the Department of Biophysics at the Medical College of Wisconsin focusing on magnetic resonance imaging (MRI) technology development. This project will be dedicated to the deep learning-driven design of MRI pulse sequences, image reconstruction algorithms, and the quantitative estimation of tissue parameters. These efforts contribute to a larger initiative aimed at enhancing the accuracy and reproducibility of quantitative MRI. The Center for Imaging Research at MCW houses two cutting-edge GE Premier 3T MRI systems, which will play a significant role in the research. We are seeking a candidate who is eager to work in a team-oriented laboratory environment that emphasizes innovation. The role includes mentoring graduate students in research methodologies, engaging in scientific publication, and preparation of grant proposals.

Primary Functions
Supervise and independently execute studies related to the project described above, including performing experiments, analyzing data, and disseminating results through presenting at conferences and writing manuscripts.

Knowledge – Skills – Abilities
Ideal candidates will have experience expertise in one or more of the following:

• MRI pulse sequence design (GE HealthCare EPIC Preferred)
• Programming in Python and C/C++
• Machine learning with PyTorch
• Excellent writing skills, as evidenced by first author publications

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Purpose
Under general supervision, provide support for department research through projects, maintenance and communication of data, and execution of laboratory experiments. Support research on the structure and dynamics and in vivo function of bacterial proteins identified as drug targets for the development of novel antibiotics.

Primary Functions

• Carry out experimental designs for sponsored research projects and perform routine experiments.
• Record and compile accurate records and communicate summaries of experimental results.
• Assist with the evaluation, interpretation, and assessment of experimental data and quality control of assays.
• Participate in meetings with principal investigator and research staff and evaluate/interpret the validity of data as needed.
• Carry out assigned duties for ordering and maintaining supply of inventories.
• Operate, calibrate, and perform routine maintenance on specialized equipment used in research.
• Prepare media and buffers and perform routine laboratory maintenance.
• Express and purify recombinant proteins from E. coli using column chromatography.
• Label, concentrate, and prepare samples for EPR spectroscopy and other biophysical studies.
• Operate specialized EPR spectroscopy instrumentation as trained.
• Carry out in vivo growth assays.
• Perform other scientific and administrative duties as assigned.

Knowledge – Skills – Abilities
Ability to meticulously carry out experiments as trained. Ability to accurately determine basic math and chemistry calculations, maintain records, and carry out experiments in a timely and organized manner. Ability to work independently with proper training. Attention to detail. Honesty. Integrity. Experience in growing bacterial cultures, making buffers and media, carrying out molecular biology and microbiology assays and purifying protein from bacteria will be highly beneficial.

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