About the Medical College of Wisconsin Linda T. and John A. Mellowes Center for Genomic Sciences and Precision Medicine
The Linda T. and John A. Mellowes Center for Genomic Sciences and Precision Medicine (Mellowes Center) at the Medical College of Wisconsin (MCW) works daily to transform the practice of precision medicine by advancing our understanding of diseases, revolutionizing how diseases are diagnosed, and personalizing treatments for patients in our community and beyond.
Mellowes Center Pillar Programs
Nationally and internationally known for its pioneering work in the fields of ’Omics, Data Science, and Systems Biology, the Center discovers and innovates across its four pillar programs:
Inherited Diseases of Children and Adults
Collaborating with national and international researchers, clinicians, patients and students, the Mellowes Center seeks to advance multidisciplinary research, offering 'Omics and Bioinformatics services and discovering the pivotal role of specific genes in inherited rare diseases.
Community & Precision Public Health
Our commitment to diversifying genomic research focuses on community-based, genomics-informed studies that integrate ethnic diversity and environmental impacts.
Precision Oncology & Cancer Genomics
By studying the genetic, epigenetic, and environmental factors influencing cancer we seek to personalize care and improve prevention, diagnosis, and treatment, and leverage precision medicine in our partnerships with the MCW Cancer Center and Michaels Rare Cancers Research Laboratories.
Systems Biology Resources in 'Omics and Bioinformatics
We advance precision medicine by developing and adapting novel technologies and methodologies for reliable genetic and epigenetic data analysis, offering state-of-the-art shared resources in 'Omics and Bioinformatics led by experienced teams.
To make these advancements possible, the Center boasts multiple state-of-the-art next generation sequencing technologies with supporting expertise in tissue, sample, and analyte processing. Our faculty use these capabilities to investigate how inter-individual variations (i.e. genetic, structural, gene expression, gene regulation, and more) impact cellular and physiologic programs across rare and common diseases, cancers, embryonic development, and the effects of environmental factors and therapeutic treatments. We also have a long-standing advanced program that leverages these technologies with structural bioinformatics to mechanistically define the underpinnings for genetic variants associated with undiagnosed congenital diseases and human cancers.
Mellowes Center Guiding Principles
Discovery & Invention
Genomic sciences and precision medicine exists on the leading edge of research as a driver that rapidly translates to meet clinical needs. We embrace the discovery and invention of ideas, approaches, and tools in order to achieve our Center’s mission. We continuously seek innovative ideas, pursue novel solutions, and test technological advances so that we can be leaders and educators across all units and areas of expertise.
Teamwork
We embrace a shared leadership structure. We celebrate that pioneering the fields of ‘Omics, Data Science, and Systems Biology requires individual and collective excellence and that we can do far more together than we could do alone. We proactively partner to formulate how to move forward amidst challenges. We value each other’s area expertise and strive to invite and facilitate each person to unleash their full creative potential.
Diversity and Inclusion
Precision medicine is built upon the knowledge that each individual is unique and diverse, all the way down to the molecular level. We apply this principle to our work environment and commit to not only recognizing but also seeking and including diverse identities, backgrounds, abilities, and perspectives. It is these differences that broaden our ideas, strengthen the way that we work, and increase not only the quality but also the impact of the outcomes of that work. We embrace the mindset of lifelong learners and approach our differences with kind curiosity and openness. We choose the temporary discomfort of discussing differences over the long-term and damaging consequences of ignoring them.
Professionalism
We strive to exemplify Mellowes Center professionalism standards by being mindful, introspective, and resilient. We aim to identify assertions so they can be assessed. We assume positive intent, ask proactive questions, and initiate growth-oriented dialogue with others. We work hard together to excel in our conduct while we achieve our goals. We are resilient in the face of constructive feedback and embrace a culture of kind accountability.
Community
We belong to our unit/lab, the Mellowes Center, the Medical College of Wisconsin, and the broader local, regional, and global communities. We demonstrate our commitment to each of these communities by participating in various engagement opportunities that also advance our goals, mission, and vision. We are stewards of our culture within and beyond our Center and build strong, cooperative relationships. We serve as a community to achieve something larger than ourselves.
Mellowes Center History
From its roots in understanding and manipulating model organisms, our Center helped establish a premier NIH-funded database for genetic, genomic, phenotype, and disease-related model organism data management program generated from research (RGD and Alliance of Genome Resources) and pioneered the first-in-the-world breakthrough using whole genome sequencing to diagnose a young boy with a rare disease (One in a Billion).
Now, the reimagined Mellowes Center adapts innovative and cutting edge technology and applies them in our pillar programs to better understand and diagnose rare diseases and rare cancers and improve individual’s knowledge of their own genomic data. These efforts make us the nationally- and internationally-known research hub that we are today.
Contact Us
Medical College of Wisconsin
8701 Watertown Plank Rd.
Milwaukee, WI 53226
(414) 955-4887
(414) 955-6516 (fax)
mellowescenterinfo@mcw.edu